411237-52-0Relevant academic research and scientific papers
A highly regio- and enantioselective organocatalyzed Michael addition of malonates to nitrodienes
Chowdhury, Raghunath,Vamisetti, Ganga B.,Ghosh, Sunil K.
, p. 516 - 522 (2014/05/06)
An organocatalyzed direct Michael addition of unsubstituted/substituted malonates, acetoacetate, or acetylacetones to conjugated nitrodienes using a cinchona alkaloid-based thiourea catalyst is disclosed. The addition products were formed in high yields and regioselectivity. The enantioselectivities of the addition products were high in most cases and could significantly be improved upon by a single recrystallization. The addition products easily undergo chemoselective nitro group reduction and subsequent lactamization with a high synthetic potential.
Highly enantioselective Michael addition of malonates to nitroolefins catalyzed by chiral bifunctional tertiary amine-thioureas based on saccharides
Li, Xiao-Juan,Liu, Kun,Ma, Hai,Nie, Jing,Ma, Jun-An
scheme or table, p. 3242 - 3246 (2009/06/25)
A series of saccharide-derived bifunctional tertiary amine-thioureas for the asymmetric Michael addition reaction have been designed and synthesized. The addition products between malonates and various nitroolefins were obtained in high yields (up to 99%)
