411238-88-5

Basic information

• Product Name: 3-HYDRAZINOCARBONYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: 1-BOC-PYRROLIDINE-3-CARBOHYDRAZIDE;1-BOC-3-HYDRAZINOCARBONYLPYRROLIDINE;3-HYDRAZINOCARBONYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;Zinc01436154;Zinc01436155;tert-butyl 3-(hydrazinecarbonyl)pyrrolidine-1-carboxylate
• CAS NO: 411238-88-5
• Molecular Formula: C₁₀H₁₉N₃O₃
• Molecular Weight: 229.28
• Mol File: 411238-88-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 395.8°Cat760mmHg
• Flash Point: 193.1°C
• Appearance: /
• Density: 1.18g/cm³
• Vapor Pressure: 1.8E-06mmHg at 25°C
• Refractive Index: 1.514
• PKA: 13.04±0.20(Predicted)
• CAS DataBase Reference: 3-HYDRAZINOCARBONYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-HYDRAZINOCARBONYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(411238-88-5)
• EPA Substance Registry System: 3-HYDRAZINOCARBONYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(411238-88-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 411238-88-5(Hazardous Substances Data)

Usage

General Description

3-Hydrazinocarbonyl-pyrrolidine-1-carboxylic acid tert-butyl ester is a chemical compound with the molecular formula C11H20N4O3. It is a tert-butyl ester derivative of 3-hydrazinocarbonyl-pyrrolidine-1-carboxylic acid, a key intermediate in the synthesis of pharmaceuticals and biologically active compounds. 3-HYDRAZINOCARBONYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is a white crystalline solid that is soluble in organic solvents. It is commonly used as a building block in the synthesis of various drugs and bioactive molecules due to its versatile reactivity and functional group compatibility. Additionally, its tert-butyl ester form provides protection to the carboxylic acid functional group, allowing for controlled and selective manipulations in chemical reactions.

InChI:InChI=1/C10H19N3O3/c1-10(2,3)16-9(15)13-5-4-7(6-13)8(14)12-11/h7H,4-6,11H2,1-3H3,(H,12,14)

Upstream product

• 122684-33-7 methyl 1-tert-butoxycarbonyl-3-pyrrolidinecarboxylate 

Downstream Products

• 1452467-45-6 tert-butyl 3-[(2-{[(2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl}hydrazinyl)carbonyl]pyrrolidine-1-carboxylate 

Relevant articles and documents

1-CYANO-PYRROLIDINE DERIVATIVES AS DUB INHIBITORS

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30). The novel compounds have formula (I): (Formula (I)) or are pharmaceutically acceptable salts thereof, wherein: R1a, R1b, R1c, R1d, R1e and R1f each independently represent hydrogen, optionally substituted C1-C6 alkyl or optionally substituted C3-C4 cycloalkyl, or R1b and R1c together form an optionally substituted C3-C6 cycloalkyl ring, or R1d and R1e together form an optionally substituted C3-C6 cycloalkyl ring; R2 represents hydrogen or optionally substituted C1-C6 alkyl; A represents an optionally further substituted 5 to 10 membered monocyclic or bicyclic heteroaryl, heterocyclyl or aryl ring; L represents a covalent bond or linker; B represents an optionally substituted 3 to 10 membered monocyclic or bicyclic heterocyclyl, heteroaryl, cycloalkyl or aryl ring; and when -A-L-B is at position x attachment to A is via a carbon ring atom of A, and either: A cannot be triazolopyridazinyl, triazolopyridinyl, imidazotriazinyl, imidazopyrazinyl or pyrrolopyrimidinyl; or B cannot be substituted with phenoxyl; or B cannot be cyclopentyl when L is an oxygen atom.

BIARYL CARBOXAMIDES

This invention provides compounds of Formula (I) which are PAFR antagonists: Formula (I) and the pharmaceutically acceptable salts thereof. The compounds are useful for treating PAF-mediated disorders, and can be used in methods for treating atherosclerosis and preventing or reducing risk for atherosclerotic disease events. The compounds are also useful for treating or ameliorating pain, e.g. inflammatory pain and/or nociceptive pain, and for treating or ameliorating autoimmune and/or inflammatory diseases, among other conditions.