41126-02-7

Upstream product

• 41125-75-1 5-(4-methoxy)phenyl-1,3,4-oxadiazol-2(3H)-one 
• 74-88-4 methyl iodide 
• 82476-11-7 2-methoxy-5-(4-methoxyphenyl)-1,3,4-oxadiazole 
• 123-11-5 4-methoxy-benzaldehyde 
• 112113-34-5 3-(4-methoxyphenyl)-1,5-dimethyl-6-oxo-verdazyl 
• 1314239-46-7 4-(4-methoxyphenyl)-2-methyl-6-phenyl-2,6,7,8-tetrahydro-1H-pyrazolo[1,2-a][1,2,4,5]tetrazin-1-one 

Relevant academic research and scientific papers

A Double Ionic Mechanism for the Chapman-like Rearrangement of Imino-ethers to N-Alkylamides, in the Solid State or in the Melt. Theoretical and Experimental Evidence

Using 5-methoxy-2-aryl-1,3,4-oxadiazoles as models it was shown that the thermal rearrangement of imino-ethers to N-alkylamides proceeds through a double ionic mechanism; kinetics measurements in the solid state and in the melt give apparent activation energies that support ab initio calculated activation enthalpies.

I2 mediated synthesis of 5-substituted-3-methyl/benzyl-1,3,4-oxadiazol-2(3H)-ones via sequential condensation/oxidative cyclization and rearrangement

A simple and efficient iodine-assisted protocol for the synthesis of 5-substituted-3-methyl/benzyl-1,3,4-oxadiazol-2(3H)-ones has been developed. The reaction involves a sequential condensation followed by tandem oxidative cyclization and rearrangement of

Verdazyl radicals as substrates for organic synthesis: A synthesis of 3-methyl-5-aryl-1,3,4-oxadiazolones

The synthesis of oxadiazolones under hydrolytic conditions is described for a series of 3-methyl-5-aryl-1,3,4-oxadiazolone compounds. The unique starting materials for the hydrolysis reaction are obtained from efficient 1,3-dipolar cycloaddition reactions

An Unusually Fast Chapman-like Thermal Rearrangement in the Solid State

Some 5-methoxy-2-aryl-1,3,4-oxadiazoles undergo a 1,3 O-to-N thermal rearrangement of the methyl group, which takes place unusually easily, and much faster in the solid state than in the melt.