41126-24-3Relevant academic research and scientific papers
Metal-Free, DBU-Mediated, Microwave-Assisted Synthesis of Benzo[c]xanthones by Tandem Reactions of Alkynyl-1,3-diketones
Liang, Yi-En,D. Barve, Balaji,Kuo, Yao-Haur,Fang, Hsu-Wei,Kuo, Ting-Shen,Li, Wen-Tai
supporting information, p. 505 - 511 (2020/12/01)
A base-mediated, green, microwave-assisted efficient preparation of a diverse benzoxanthone library from variety of readily accessible γ-alkynyl 1,3-diketones is reported. The synthesis is based on tandem reactions involving intramolecular cyclization, propargyl-allenyl isomerization, and electrocyclization in one pot. Some of the benzoxanthones are also synthesized by the one-pot reaction of 1,3-diketone and alkynyl bromide under basic heating conditions. This transformation also results in the construction of one new C?C bond and one new C?O bond. (Figure presented.).
Identification of new aryl hydrocarbon receptor (AhR) antagonists using a zebrafish model
Jeong, Jieun,Kim, Kun-Hee,Kim, Dong-Young,Chandrasekaran, Gopalakrishnan,Kim, Minhee,Pagire, Suvarna H.,Dighe, Mahesh,Choi, Eun Young,Bak, Su-Min,Kim, Eun-Young,Shin, Myung-Geun,Choi, Seok-Yong,Ahn, Jin Hee
, (2019/08/01)
A new series of 1,3-diketone, heterocyclic and α,β-unsaturated derivatives were synthesized and evaluated for their AhR antagonist activity using zebrafish and mammalian cells. Compounds 1b, 2c, 3b and 5b showed significant AhR antagonist activity in a transgenic zebrafish model. Among them, compound 3b, and 5b were found to have excellent AhR antagonist activity with IC50 of 3.36 nM and 8.3 nM in a luciferase reporter gene assay. In stem cell proliferation assay, compound 5b elicited marked HSC expansion.
