41137-87-5

Usage

Uses

Used in Pharmaceutical Industry:
Hirsutene is used as an anti-inflammatory agent for its potent ability to reduce inflammation, which can be beneficial in treating various inflammatory conditions.
Hirsutene is used as an antifungal agent for its demonstrated effectiveness against a range of fungi, making it a potential candidate for treating fungal infections.
Used in Cancer Therapy:
Hirsutene is used as a potential cancer therapeutic agent due to its significant inhibitory effects on the growth of various cancer cell lines, offering a new avenue for cancer treatment.
Used in Antimicrobial Applications:
Hirsutene is used as an antimicrobial agent for its activity against a variety of pathogens, including bacteria and fungi, which can be utilized in the development of new antimicrobial drugs.

Upstream product

• 79067-88-2 (E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-4-hepten-3-one 
• 67-56-1 methanol 
• 55303-93-0 oregonin 
• 64-17-5 ethanol 
• 458-37-7 curcumin 
• 36062-05-2 hexahydrocurcumin 
• 36062-04-1 1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione 

Downstream Products

• 55094-76-3 (E)-1,7-Bis-(3,4-dimethoxy-phenyl)-hept-4-en-3-one 

Relevant academic research and scientific papers

New diarylheptanoids from Alnus japonica and their antioxidative activity

In the course of research on the bioactive constituents of woody plants in the Cyugoku area of Japan, a methanol extract of the leaves of Alnus japonica were found to have strong antioxidative activity. Ethyl acetate soluble and n-buthanol soluble fractio

A new diarylheptanoid glycoside from the stem bark of Alnus hirsuta and protective effects of diarylheptanoid derivatives in human HepG2 cells

To search for secondary metabolites of Alnus hirsuta (Betulaceae), various chromatographic separations of the ethyl acetate soluble fraction of the stem bark of A. hirsuta led to the isolation of a new diarylheptanoid glycoside, (3R)-1,7-bis-(4-dihydroxyphenyl)-3-heptanol 3-O-β-D- glucopyranosyl(1→3)-β-D-xylopyranoside (13) and twelve diarylheptanoid derivatives, namely, oregonin (1), rubranoside A (2), hirsutanonol 5-O-β-D-glucopyranoside (3), rubranoside B (4), rubranoside C (5), hirsutanonol (6), hirsutenone (7), (5S)-O-methylhirsutanonol (8), platyphylloside (9), platyphyllonol 5-O-β-D-xylopyranoside (10), aceroside VII (11) and platyphyllenone (12). Isolates were assessed for their hepatoprotective effects against tert-butylhydroperoxide (t-BHP)-induced toxicity in HepG2 cells. Of these isolates, compounds 1 - 8 showed significant hepatoprotective effects on t-BHP-induced damage to HepG2 cells, with 8 exhibiting the greatest protective effect (50.7±3.7% at a concentration of 10 μM).

Synthesis of gingerenone-A and hirsutenone

Gingerenone-A 5, a diarylheptenone from Zingiber officinale, has been synthesized from vanillin 1 in four steps with an overall yield of 15%. Demethylation of 5 with AlCl3 gives hirsutenone 6, a metabolite of Alnus hirsute, in 36% yield. The spectral data of 5 and 6 are in agreement with those of natural metabolites 5 and 6 and both the compounds exhibited weak antibacterial activity.