4115-14-4

Upstream product

• 62-55-5 thioacetamide 
• 93808-51-6 (3-methyl-[1,2,4]thiadiazol-5-yl)-malonic acid di-tert-butyl ester 
• 29517-84-8 (3-methyl-[1,2,4]thiadiazol-5-yl)-acetic acid 
• 75-05-8 acetonitrile 

Downstream Products

• 91093-50-4 3-methyl-5-(4-nitro-styryl)-[1,2,4]thiadiazole 

Relevant academic research and scientific papers

Facile access to 3,5-symmetrically disubstituted 1,2,4-thiadiazoles through phosphovanadomolybdic acid catalyzed aerobic oxidative dimerization of primary thioamides

In the presence of Keggin-type phosphovanadomolybdic acids, e.g., H 6PV3Mo9O40, oxidative dimerization of various kinds of primary thioamides including aromatic, heterocyclic, and aliphatic ones efficiently proceeded to give the corresponding 3,5-disubstituted 1,2,4-thiadiazoles in excellent yields. This journal is the Partner Organisations 2014.

Eosin y catalyzed visible-light-driven aerobic oxidative cyclization of thioamides to 1,2,4-thiadiazoles

A new approach for an efficient metal-free synthesis of 1,2,4-thiadiazoles from primary thioamides using visible light and air in the presence of eosin Y as a photoredox catalyst is reported. The protocol involves an aerobic oxidative cyclization of thioamides via the formation of C-N and C-S bonds to afford excellent yields of the products in a simple one-pot operation under mild conditions. Georg Thieme Verlag Stuttgart · New York.

Oxidation of methyl groups in the reaction of sulfur homopolyatomic cations with acetonitrile: Formation and crystal structure of the novel trithietanylium ring

RCN (R = C6F5, Me) reacts with S(n)(AsF6)2 (n = 4, 8) in liquid SO2 to give the corresponding 3,5-disubstituted-1,2,4 thiadiazoles, and also, in the MeCN case, the tricyclic trication 4 containing the

THE REACTION OF t-BUTYL HYPOCHLORITE WITH THIOCARBONYL COMPOUND - A CONVENIENT METHOD FOR THE TRANSFORMATION

The reaction of t-butyl hypochlorite with different thiocarbonyl compounds has been studied.Primary thioamides 1a-c give 1,2,4-thiadiazole derivatives.N-Phenylthiourea 4a gives 5-imino-4-phenyl-3-phenylamino-4,5-dihydro-1,2,4-thiadiazoline 15.Secondary and tertiary thioamides 2a-d, N-methyl-2-thiopyrrolidinone 3, N,N'-dicyclohexylthiourea 4b, N,N,N'-trimethylthiourea 4c, 5-ethyl-5-phenylthiobarbituric acid 5, xanthione 7a, Mischler's thioketone 7b, thiocoumarin 8, O-ethylthiobenzoate 9, O,O-diphenylthiocarbonate 10, di-p-tolyl and o-phenylene trithiocarbonates 11 and 12 have all afforded the oxigen analogues.N,N-Dimethyl-S-phenyldithiocarbonate 6 produces a mixture of di-, tri-, and tetrasulfides.A mechanism for the transformation is suggested in accordance with the Hard and Soft Acids and Bases (HSAB) principle.

Bis(p-methoxyphenyl) Selenoxide as a Mild and Selective Oxidizing Agent

The title compound oxidized thiolsto disulfides, sulfides to sulfoxides, hydroquinone or catechol to benzoquinones, and phosphine to phosphine oxide in high yields under very mild conditions.In addition, it functioned as a useful reagent for the syntheses of 1,2,4-thiadiazole derivatives from thioureas or thioamides.