41167-36-6

Upstream product

• 538-58-9 1,5-diphenyl-1,4-pentadiene-3-one 
• 108-59-8 malonic acid dimethyl ester 
• 35225-79-7 dibenzylideneacetone 
• 6287-64-5 1,5-Diphenyl-1,4-pentadien-3-one 

Downstream Products

• 79815-46-6 4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid 
• 222529-14-8 2,6-diphenyl-cyclohexane-1,4-dione 
• 81794-19-6 dimethyl t-3,c-5-dibromo-4-oxo-r-2,t-6-diphenylcyclohexane-1,1-dicarboxylate 
• 81794-18-5 dimethyl c-3-bromo-4-oxo-r-2,t-6-diphenylcyclohexane-1,1-dicarboxylate 
• 81794-18-5 dimethyl t-3-bromo-4-oxo-r-2,t-6-diphenylcyclohexane-1,1-dicarboxylate 
• 81794-32-3 dimethyl 5,5-dibromo-4-oxo-2,6-diphenylcyclohex-2-ene-1,1-dicarboxylate 
• 81794-30-1 dimethyl 3-bromo-4-oxo-2,6-diphenylcyclohex-2-ene-1,1-dicarboxylate 
• 81794-31-2 dimethyl 5-bromo-4-oxo-2,6-diphenylcyclohex-2-ene-1,1-dicarboxylate 
• 81794-25-4 dimethyl 4-oxo-2,6-diphenylcyclohex-2-ene-1,1-dicarboxylate 
• 81794-26-5 dimethyl 4-oxo-2,6-diphenylcyclohexa-2,5-dieno-1,1-dicarboxylate 
• 81794-19-6 dimethyl t-3,t-5-dibromo-4-oxo-r-2,t-6-diphenylcyclohexane-1,1-dicarboxylate 
• 81794-21-0 dimethyl 3,3,5,5-tetrabromo-4-oxo-trans-2,6-diphenylcyclohexane-1,1-dicarboxylate 
• 81794-20-9 dimethyl 3,3,t-5-tribromo-4-oxo-r-2,t-6-diphenylcyclohexane-1,1-dicarboxylate 
• 81794-22-1 dimethyl 3,3-dibromo-4-oxo-r-2,t-6-diphenylcyclohexane-1,1-dicarboxylate 

Relevant academic research and scientific papers

Synthesis, characterization and evaluation of topical antiinflammatory activity of dimethyl 4-oxo-2,6-diphenylcyclohexane-1,1-dicarboxylate

An attempt was made to synthesize a topical preparation of an active compound that has a potent antiinflammatory activity. Dimethyl 4- oxo-2,6-diphenylcyclohexane-1,1-dicarboxylate (II) was prepared by aldol condensation of benzaldehyde and acetone followed by Michael addition of dimethyl malonate. The optimum concentration of the compound was determined by comparing the antiinflammatory effect of ointment preparations at different concentrations. The antiinflammatory effects were studied by using carrageenan-induced paw edema method in rat and xylene induced rat ear edema. Good effect was observed with ointment containing 4 % and 5 % of the compound II concentration. The results showed that the drug had an obvious antiinflammatory effect as an external preparation and the activity is comparable to that of the standard ointment.

Polycyclic dihydroxy compounds and methods for preparation

A dihydroxy aromatic compound having a Formula (I) wherein R1 is selected from the group consisting of a cyano functionality, a nitro functionality, an aliphatic functionality having 1 to 10 carbons, an aliphatic ester functionality having 2 to 10 carbons, a cycloaliphatic ester functionality having 4 to 10 carbons and an aromatic ester functionality having 4 to 10 carbons; R2 is selected from the group consisting of a cyano functionality, a nitro functionality, an aliphatic ester functionality having 2 to 10 carbons, a cycloaliphatic ester functionality having 4 to 10 carbons and an aromatic ester functionality having 4 to 10 carbons; and each R3 and R4, at each occurrence, can be the same or different and are independently at each occurrence an aliphatic functionality having 1 to 10 carbons or a cycloaliphatic functionality having 3 to 10 carbons, “n” is an integer having a value 0 to 4 and “m” is an integer having a value 0 to 4.

Michael addition approach for the synthesis of novel spiro compounds and 2-substituted malonic acid derivatives from Meldrum's acid

Novel routes for the synthesis of spiro derivatives of Meldrum's acid and 2-substituted malonic acid derivatives have been developed. Meldrum's acid was monoalkylated using a Michael addition reaction. Mono-Michael adducts were then alkylated using substituted haloalkanes, which on condensation gave spiro derivatives of Meldrum's acid. Bis Michael addition of Meldrum's acid with 1,5-diaryl-1,4-pentadien-3-one gave directly a spiro derivative of Meldrum's acid. These compounds and bis alkylated Meldrum's acid derivatives, on acidic methanolysis gave 2-substituted malonic acids.

Michael reaction of stabilized carbon nucleophiles catalyzed by [RuH2(PPh3)4]

The Michael reaction of active methylene compounds lacking cyano groups such as malonates, β-ketoesters, 1,3-diketones, 1,1-disulfones, nitrocompounds, Meldrum acid, and anthrone with common acceptors proceeds in acetonitrile solution in the presence of [RuH2(PPh3)4] as the catalyst. Cyano acetates, more acidic than malonates in organic solvents, are also excellent substrates for this reaction. In a number of cases, intramolecular aldol reactions catalyzed by [RuH2(PPh3)4] were also observed as side reactions. Catalysis by other ruthenium and rhodium complexes has been examined. Selectivity studies performed with malonate and disulfone donors indicate that the catalyst selectively activates Michael donors that can coordinate with ruthenium(II). Additionally, it has been shown that the reaction requires the presence of free phosphine. Therefore, the Michael reaction of stabilized enolates appears to be a ruthenium- and phosphine-catalyzed reaction. From a practical point of view, the use of readily prepared [RuH2(PPh3)4] as the catalyst in acetonitrile provided the best solution for the Michael reaction of active methylene compounds.

Bromo-derivatives of Dimethyl 4-Oxo-trans-2,6-diphenylcyclohexane-1,1-dicarboxylate and Their Dehydrobromination

The structures and stereochemistry of various bromo-derivatives of dimethyl 4-oxo-trans-2,6-diphenylcyclohexane-1,1-dicarboxylate are reported.The dehydrobromination of these derivatives is described and, in some cases a phenol is produced by demethoxycar