41167-36-6

Basic information

• Product Name: dimethyl 4-oxo-2,6-diphenylcyclohexane-1,1-dicarboxylate
• Synonyms: dimethyl 4-oxo-2,6-diphenylcyclohexane-1,1-dicarboxylate
• CAS NO: 41167-36-6
• Molecular Weight: 366.414
• Mol File: 41167-36-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: dimethyl 4-oxo-2,6-diphenylcyclohexane-1,1-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl 4-oxo-2,6-diphenylcyclohexane-1,1-dicarboxylate(41167-36-6)
• EPA Substance Registry System: dimethyl 4-oxo-2,6-diphenylcyclohexane-1,1-dicarboxylate(41167-36-6)

Safety Data

• Hazardous Substances Data: 41167-36-6(Hazardous Substances Data)

Upstream product

• 35225-79-7 dibenzylideneacetone 
• 108-59-8 malonic acid dimethyl ester 
• 6287-64-5 1,5-Diphenyl-1,4-pentadien-3-one 
• 538-58-9 1,5-diphenyl-1,4-pentadiene-3-one 

Downstream Products

• 79803-35-3 4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid methyl ester 
• 81794-19-6 dimethyl t-3,c-5-dibromo-4-oxo-r-2,t-6-diphenylcyclohexane-1,1-dicarboxylate 
• 81794-18-5 dimethyl c-3-bromo-4-oxo-r-2,t-6-diphenylcyclohexane-1,1-dicarboxylate 
• 81794-18-5 dimethyl t-3-bromo-4-oxo-r-2,t-6-diphenylcyclohexane-1,1-dicarboxylate 
• 81794-32-3 dimethyl 5,5-dibromo-4-oxo-2,6-diphenylcyclohex-2-ene-1,1-dicarboxylate 
• 81794-30-1 dimethyl 3-bromo-4-oxo-2,6-diphenylcyclohex-2-ene-1,1-dicarboxylate 
• 81794-31-2 dimethyl 5-bromo-4-oxo-2,6-diphenylcyclohex-2-ene-1,1-dicarboxylate 
• 81794-25-4 dimethyl 4-oxo-2,6-diphenylcyclohex-2-ene-1,1-dicarboxylate 
• 81794-26-5 dimethyl 4-oxo-2,6-diphenylcyclohexa-2,5-dieno-1,1-dicarboxylate 
• 222529-14-8 2,6-diphenyl-cyclohexane-1,4-dione 
• 79815-46-6 4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid 
• 81794-19-6 dimethyl t-3,t-5-dibromo-4-oxo-r-2,t-6-diphenylcyclohexane-1,1-dicarboxylate 
• 81794-21-0 dimethyl 3,3,5,5-tetrabromo-4-oxo-trans-2,6-diphenylcyclohexane-1,1-dicarboxylate 
• 81794-20-9 dimethyl 3,3,t-5-tribromo-4-oxo-r-2,t-6-diphenylcyclohexane-1,1-dicarboxylate 

Relevant articles and documents

Synthesis, characterization and evaluation of topical antiinflammatory activity of dimethyl 4-oxo-2,6-diphenylcyclohexane-1,1-dicarboxylate

An attempt was made to synthesize a topical preparation of an active compound that has a potent antiinflammatory activity. Dimethyl 4- oxo-2,6-diphenylcyclohexane-1,1-dicarboxylate (II) was prepared by aldol condensation of benzaldehyde and acetone followed by Michael addition of dimethyl malonate. The optimum concentration of the compound was determined by comparing the antiinflammatory effect of ointment preparations at different concentrations. The antiinflammatory effects were studied by using carrageenan-induced paw edema method in rat and xylene induced rat ear edema. Good effect was observed with ointment containing 4 % and 5 % of the compound II concentration. The results showed that the drug had an obvious antiinflammatory effect as an external preparation and the activity is comparable to that of the standard ointment.

Michael addition approach for the synthesis of novel spiro compounds and 2-substituted malonic acid derivatives from Meldrum's acid

Novel routes for the synthesis of spiro derivatives of Meldrum's acid and 2-substituted malonic acid derivatives have been developed. Meldrum's acid was monoalkylated using a Michael addition reaction. Mono-Michael adducts were then alkylated using substituted haloalkanes, which on condensation gave spiro derivatives of Meldrum's acid. Bis Michael addition of Meldrum's acid with 1,5-diaryl-1,4-pentadien-3-one gave directly a spiro derivative of Meldrum's acid. These compounds and bis alkylated Meldrum's acid derivatives, on acidic methanolysis gave 2-substituted malonic acids.

Bromo-derivatives of Dimethyl 4-Oxo-trans-2,6-diphenylcyclohexane-1,1-dicarboxylate and Their Dehydrobromination

The structures and stereochemistry of various bromo-derivatives of dimethyl 4-oxo-trans-2,6-diphenylcyclohexane-1,1-dicarboxylate are reported.The dehydrobromination of these derivatives is described and, in some cases a phenol is produced by demethoxycar