41173-36-8

Basic information

• Product Name: 1-(4-CHLORO-2-NITROPHENYL)PYRROLIDINE
• Synonyms: 1-(4-CHLORO-2-NITROPHENYL)PYRROLIDINE;BUTTPARK 45\09-21
• CAS NO: 41173-36-8
• Molecular Formula: C₁₀H₁₁ClN₂O₂
• Molecular Weight: 226.66
• Mol File: 41173-36-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 357.5°Cat760mmHg
• Flash Point: 170°C
• Appearance: /Solid
• Density: 1.351g/cm³
• Vapor Pressure: 2.72E-05mmHg at 25°C
• Refractive Index: 1.606
• CAS DataBase Reference: 1-(4-CHLORO-2-NITROPHENYL)PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-CHLORO-2-NITROPHENYL)PYRROLIDINE(41173-36-8)
• EPA Substance Registry System: 1-(4-CHLORO-2-NITROPHENYL)PYRROLIDINE(41173-36-8)

Safety Data

• Hazardous Substances Data: 41173-36-8(Hazardous Substances Data)

Usage

General Description

1-(4-chloro-2-nitrophenyl)pyrrolidine is a chemical compound with the molecular formula C10H11ClN2O2. It is a pyrrolidine derivative that contains a chloro-nitrophenyl group, which gives it potential applications as a building block in organic synthesis. 1-(4-CHLORO-2-NITROPHENYL)PYRROLIDINE may be used to create other pharmaceutical or agrochemical intermediates, as well as being a useful tool in medicinal chemistry. Its unique structure and functional groups make it an important molecule for research and development in the chemical and pharmaceutical industries.

InChI:InChI=1/C10H11ClN2O2/c11-8-3-4-9(10(7-8)13(14)15)12-5-1-2-6-12/h3-4,7H,1-2,5-6H2

Upstream product

• 123-75-1 pyrrolidine 
• 89-61-2 2,5-dichloronitrobenzene 
• 120-94-5 1-Methylpyrrolidine 
• 6943-00-6 1-(4-chlorophenyl)pyrrolidine-2,5-dione 
• 4280-30-2 1-(4-chlorophenyl)pyrrolidine 

Downstream Products

• 59504-29-9 5-chloro-2-(pyrrolidin-1-yl)aniline 

Relevant articles and documents

Specific features of nucleophilic substitution in 1-chloro-3,4- dinitrobenzene

Effects of the solvent, temperature, and nucleophile nature on the selectivity of nucleophilic substitution in 1-chloro-3,4-dinitrobenzene were studied, and optimal conditions were found for the synthesis and isolation of particular products.

Aromatic Nucleophilic Substitution of Halobenzenes with Amines under High Pressure

The nucleophilic substitution reactions of aromatic halides having electron-attracting groups on ortho or para position with various primary and secondary amines were accelerated by high pressure to give the corresponding N-substituted anilines in high yields.The bulkiness of amines affects its reactivity to lower the yields of the products.Although the secondary amines are usually less reactive than primary amines, cyclic secondary amines such as morpholine, piperidine, and pyrrolidine were found very reactive. 1,4-Diazabicyclooctane and quinuclidine gave N-quarternary ammonium halides in high yields in contrast to the low reactivity of acyclic tertiary amines.Dichloro- and trichloro-nitrobenzenes also react with diethylamine, pyrrolidine, and morpholine to give mono-, di-, and trisubstitution products depending upon the amount of amine and the position of nitro group in these chlorides.