41198-89-4

Usage

Physical state

Colorless liquid

Odor

Slightly fruity

Applications

a. Intermediate in the synthesis of pharmaceuticals
b. Intermediate in the synthesis of agrochemicals
c. Intermediate in the synthesis of other organic compounds
d. Solvent
e. Production of dyes and pigments

Functional groups

a. Cyclohexene
b. Carbonitrile

Toxicity

Low toxicity

Safety

Generally regarded as safe for use in various industrial processes

Upstream product

• 933-45-9 1-hydroxy-4-methyl-cyclohexanecarbonitrile 
• 31053-83-5 4-methyl-1-cyclohexenyl chloride 
• 151-50-8 potassium cyanide 
• 97540-74-4 4-Methyl-cyclohex-1-enecarbaldehyde oxime 
• 589-92-4 1-methylcyclohexan-4-one 

Downstream Products

• 100860-12-6 4-methyl-cyclohex-1-enecarboxylic acid amide 
• 75233-42-0 4-Methyl-1-[1-methyl-2-nitro-3-(tetrahydro-pyran-2-yloxy)-propyl]-cyclohex-2-enecarbonitrile 
• 34147-56-3 4-methyl-1-cyclohexanemethylamine 
• 75233-43-1 1-Cyano-1-(4-hydroxy-3-nitro-2-butyl)-4-methyl-2-cyclohexene 

Relevant academic research and scientific papers

CYCLOALKYLNITRILE PYRAZOLE CARBOXAMIDES AS JANUS KINASE INHIBITORS

Cycloalkylnitrile pyrazole carboxamides as JAK inhibitors useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer are provided.

One-pot Conversion of Allylic Nitro Compounds Into Nitriles with Carbon Disulphide under Phase-transfer Catalysis Conditions

An one-pot synthesis of allylic nitriles 3 from the corresponding nitro derivatives 1 is described.In the first step the substrates 1 are reduced to the oximes 2 by carbon disulphide in the presence of wet potassium carbonate, in solid-liquid PTC conditions.In the second, the formed oximes 2 are dehydrated by adding more CS2 and 15percent aqueous NaOH.

Cyanation of 1-Halocycloalkenes Catalyzed by Tetracyanocobaltate(I). Convenient Synthesis of 1-Cyanocycloalkenes

1-Cyanocycloalkenes (1-cyanocyclopentene, -hexene, -heptene, and -octene) were readily synthesized by catalytic cyanation of the corresponding 1-halocycloalkenes with tetracyanocobaltate(I).Reactivities of methyl-substituted 1-chlorocyclohexenes were lower than that of 1-chlorocyclohexene, and 1-chloro-2-methylcyclohexene scarecely reacted.Hydrogenation and isomerization of 1-cyanocycloalkenes were observed only with 1-cyanocycloheptene and 1-cyano-6-methylcyclohexene, respectively.

Synthetic Studies toward Verrucarol. 1. Synthesis of the AB Ring System

A synthetic route to the AB ring system of verrucarol is described.After two routes employing intramolecular cyclization failed, the Diels-Alder reaction of methyl coumalate and isoprene afforded bicyclic lactone 13.Transformation of 13 into hydroxy lacto