41201-60-9

Usage

Uses

Used in Pharmaceutical Industry:
SULINDAC INTERMEDIATE is used as a crucial component in the synthesis of Sulindac, a non-steroidal anti-inflammatory drug (NSAID). It is utilized for the treatment of various conditions such as arthritis, acute gout, and bursitis. The effectiveness of Sulindac in these applications is attributed to its role as an NSAID, which helps in reducing inflammation, pain, and stiffness associated with these conditions.

InChI:InChI=1/C18H17FS/c1-12-9-14-11-15(19)5-8-17(14)18(12)10-13-3-6-16(20-2)7-4-13/h3-8,11H,9-10H2,1-2H3

Upstream product

• 874-87-3 1-(chloromethyl)-4-methylthiobenzene 
• 41201-58-5 5-Fluoro-2-Methyl-Indan-1-One 

Downstream Products

• 41201-62-1 (+/-)-6-Fluoro-3-(4-methanesulfinylbenzyl)-2-methyl-1H-indene 
• 38194-50-2 Sulindac 

Relevant academic research and scientific papers

Esters and amides of substituted indenyl acetic acids

Esters and amides of substituted indenyl acetic acids of the formula: n is an integer of at least 2;, Q is a deprotonated residue of polymer or macromolecular structure having a molecular weight of at least about 1000 containing at least two primary and/or secondary amino groups and/or hydroxy groups;, R1 is selected from hydrogen, lower alkyl, or haloalkyl;, R2 is selected from hydrogen or alkyl;, R3 and R4 are one or more members each independently chosen from hydrogen, alkyl, acyloxy, alkoxy, nitro, amino, acylamino, alkylamino, diakylamino, dialkylaminoalkyl, sulfamyl, alkythio, mercapto, hydroxy, hydroxyalkyl, alkylsulfonyl, halogen, cyano, carboxyl, carbalkoxy, carbamido, haloalkyl or cycloalkoxy; and, R5 is selected from alkylsulfenyl, alkylsulfinyl or alkylsulfonyl. are useful in the treatment of colonic polyps.

Chemical compounds and processes

Haloalkyl derivatives of aromatic compounds are prepared via reaction with dialkoxy or aralkoxy alkanes in the presence of a Lewis acid.