412011-51-9

Basic information

• Product Name: Cyclobutaneacetic acid, 2-acetyl-1-methyl- (9CI)
• Synonyms: Cyclobutaneacetic acid, 2-acetyl-1-methyl- (9CI)
• CAS NO: 412011-51-9
• Molecular Formula: C9H14O3
• Molecular Weight: 170.20566
• Product Categories: ACETYLGROUP
• Mol File: 412011-51-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Cyclobutaneacetic acid, 2-acetyl-1-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclobutaneacetic acid, 2-acetyl-1-methyl- (9CI)(412011-51-9)
• EPA Substance Registry System: Cyclobutaneacetic acid, 2-acetyl-1-methyl- (9CI)(412011-51-9)

Safety Data

• Hazardous Substances Data: 412011-51-9(Hazardous Substances Data)

Upstream product

• 73416-59-8 2,5-dimethylbicyclo[3.2.0]hept-2-ene 

Downstream Products

• 55760-16-2 2-isopropenyl-1-methyl-1-cyclobutaneacetic acid 
• 29578-30-1 cis-1-methyl-2-(1-methylethenyl)-cyclobutaneacetic acid 

Relevant articles and documents

An asymmetric synthesis of (+)-grandisol, a constituent of the aggregation pheromone of the cotton boll weevil, via a kinetic resolution

A novel approach to the asymmetric synthesis of (+)-grandisol, (1R,2S)-isopropenyl-1-methylcyclobutaneethanol, involves the use of catalytic kinetic resolution of a primary allylic alcohol, [(1RS,5SR)-5-methylbicyclo[3.2.0]hept-2-en-2-yl] methanol. The allylic alcohol is prepared in four steps from simple achiral materials involving the use of a modified Shapiro reaction. The resolved alcohol (95% ee) is then reduced in two steps to the corresponding methyl alkene, (1S,5R)-2,5-dimethylbicyclo[3.2.0]hept-2-ene. This alkene is converted to (+)-grandisol (95% ee), in three steps, by modified literature procedures.