412014-53-0Relevant academic research and scientific papers
Design and synthesis of (E)-1,1,2-triarylethenes: Novel inhibitors of the cyclooxygenase-2 (COX-2) isozyme
Uddin, Md. Jashim,Rao, P.N. Praveen,McDonald, Robert,Knaus, Edward E.
, p. 439 - 442 (2007/10/03)
A novel class of acyclic 1,1,2-triaryl (E)-ethenes was designed that were synthesized via an (E)-selective Takeda olefination reaction. Among the group of compounds evaluated, (E)-2-(4-fluorophenyl)-1-(4-methylsulfonylphenyl)-1- phenylethene (10c) emerged as the most potent (COX-2 IC50 = 0.0316 μM), and selective (selectivity index > 3164), COX-2 inhibitor.
