412034-81-2Relevant articles and documents
Studies Targeting Ryanodol Result in an Annulation Reaction for the Synthesis of a Variety of Fused Carbocycles
Karmakar, Rajdip,Rheingold, Arnold L.,Micalizio, Glenn C.
, p. 6126 - 6129 (2019/08/26)
An annulation reaction is described to access a range of polycyclic and highly oxygenated carbocycles. First developed in an approach to the synthesis of ryanodol, metallacycle-mediated annulative diketone-alkyne coupling defines a framework for realization of new retrosynthetic relationships for complex molecule synthesis. In addition to demonstrating this reaction in the context of forging distinct carbocyclic systems, including those featuring a seven-membered ring, the choice of quenching reagent leads to unique reaction outcomes.
Titanocene catalysed 5-exo cyclisations of unsaturated epoxides- reagent control in radical chemistry
Gansaeuer,Pierobon,Bluhm
, p. 2500 - 2520 (2007/10/03)
A synthetic route to carbocyclic and heterocyclic [3.3.0], [4.3.0] and [5.3.0] systems containing pyrrolidine and tetrahydrofuran units and various other tetrahydrofuran derivatives is presented. The products are of relevance for natural product synthesis and for the synthesis of biologically active compounds. The titanocene catalysed reactions utilises readily available unsaturated epoxides as substrates. A model explaining the diastereoselectivity of cyclisation is presented that should allow for rational design of more selective catalysts.
