41214-64-6Relevant academic research and scientific papers
Synthesis of aminocarbonyl N-Acylhydrazones by a three-component reaction of isocyanides, hydrazonoyl chlorides, and carboxylic acids
Giustiniano, Mariateresa,Meneghetti, Fiorella,Mercalli, Valentina,Varese, Monica,Giustiniano, Francesco,Novellino, Ettore,Cesare Tron, Gian
, p. 5332 - 5335 (2014)
A novel one-pot multicomponent synthesis of α-aminocarbonyl N-acylhydrazones starting from readily available hydrazonoyl chlorides, isocyanides, and carboxylic acids is reported. The strategy exploits the ability of the carboxylic acid as a third component to suppress all competing reactions between nitrile imines and isocyanides, channeling the course of the reaction toward the formation of this novel class of compounds. (Chemical Equation Presented).
