412271-43-3

Upstream product

• 53606-06-7 4-(methylsulfonyl)benzyl bromide 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 546-67-8 lead(IV) tetraacetate 
• 180302-63-0 cyclohexyl (4-methylsulfonyl)benzyl ketone 

Relevant academic research and scientific papers

4-Aryl/cycloalkyl-5-phenyloxazole derivatives as selective COX-2 inhibitors

A series of 4-aryl/cycloalkyl-5-phenyloxazole derivatives was synthesized and evaluated for their ability to inhibit cyclooxygenase-2 (COX-2) and cyclooxygenase-1 (COX-1). These compounds were found to be potent and selective COX-2 inhibitors.

Oxazole derivatives and use thereof

Oxazole derivatives of the formula (I) STR1 wherein one of R and R1 is a methylsulfonylphenyl, an aminosulfonyl-phenyl or an alkylaminosulfonylphenyl, and the other is a cycloalkyl having 5 to 7 carbon atoms which is optionally substituted by lower alkyl, a thienyl optionally substituted by lower alkyl or halogen atom or a furanyl optionally substituted by lower alkyl or halogen atom, and R2 is a lower alkyl, and pharmaceutically acceptable salts thereof. The oxazole derivatives and pharmaceutically acceptable salts thereof have superior antipyretic action, analgesic action, anti-inflammatory action, and particularly, selective inhibitory action on cyclooxygenase-2 (COX-2), and are expected to be useful as an antipyretic agent, an analgesic agent and an anti-inflammatory agent with less side-effects such as disorders in the digestive tract.