412272-46-9

Basic information

• Product Name: o-iodobenzyl p-tolyl sulfone
• Synonyms: o-iodobenzyl p-tolyl sulfone
• CAS NO: 412272-46-9
• Molecular Weight: 372.227
• Mol File: 412272-46-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: o-iodobenzyl p-tolyl sulfone(CAS DataBase Reference)
• NIST Chemistry Reference: o-iodobenzyl p-tolyl sulfone(412272-46-9)
• EPA Substance Registry System: o-iodobenzyl p-tolyl sulfone(412272-46-9)

Safety Data

• Hazardous Substances Data: 412272-46-9(Hazardous Substances Data)

Upstream product

• 5159-41-1 2-iodobenzyl alcohol 
• 824-79-3 sodium 4-methylbenzenesulfinate 

Downstream Products

• 447464-37-1 2-biphenylylmethyl p-tolyl sulfone 
• 447464-69-9 ethyl (E)-3-[2-(2-phenyl-1-ethynyl)phenyl]-2-propenoate 
• 447464-51-9 ethyl (E)-3-[2-(p-toluenesulfonylmethyl)phenyl]-2-propenoate 
• 447464-42-8 C₂₂H₁₈O₂S 

Relevant articles and documents

Synthetic applications of o- and p-halobenzyl sulfones as zwitterionic synthons: Preparation of Ortho-substituted cinnamates and biarylacetic acids

The synthetic applications of o-halobenzyl and p-halobenzyl sulfones as precursors of 1,3- and 1,5-zwitterionic synthons, respectively, are described. Their α-sulfonyl carbanions, generated by means of the phosphazene base P2-Et or BuLi or K2CO3 under PTC conditions, reacted with different electrophiles such as alkyl halides, aldehydes, and electrophilic olefins. Palladium-catalyzed cross-coupling processes such as Heck, Suzuki, and Sonogashira reactions can be efficiently performed at the halogen atom. These two sequential functionalization processes are applied to the synthesis of ortho-substituted cinnamates and pharmaceuticals belonging to the family of p-biarylacetic acids such as 4-biphenylacetic acid, namoxyrate, xenyhexenic acid, and biphenylpropionic acid.