412302-21-7

Basic information

• Product Name: ethyl [2-[1-[4-(dimethylamino)-3,3-diphenyl-4-oxobutyl]piperidin-4-yl]phenoxy]acetate
• Synonyms: ethyl [2-[1-[4-(dimethylamino)-3,3-diphenyl-4-oxobutyl]piperidin-4-yl]phenoxy]acetate
• CAS NO: 412302-21-7
• Molecular Weight: 528.692
• Mol File: 412302-21-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl [2-[1-[4-(dimethylamino)-3,3-diphenyl-4-oxobutyl]piperidin-4-yl]phenoxy]acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl [2-[1-[4-(dimethylamino)-3,3-diphenyl-4-oxobutyl]piperidin-4-yl]phenoxy]acetate(412302-21-7)
• EPA Substance Registry System: ethyl [2-[1-[4-(dimethylamino)-3,3-diphenyl-4-oxobutyl]piperidin-4-yl]phenoxy]acetate(412302-21-7)

Safety Data

• Hazardous Substances Data: 412302-21-7(Hazardous Substances Data)

Upstream product

• 105-36-2 ethyl bromoacetate 
• 412302-13-7 N,N-dimethyl-2,2-diphenyl-4-[4-(2-hydroxyphenyl)piperidin-1-yl]butanamide 
• 105-39-5 chloroacetic acid ethyl ester 
• 161609-76-3 4-(2-hydroxyphenyl)-piperidine 
• 58333-75-8 4-(2-methoxyphenyl)piperidine 

Relevant articles and documents

2,2-DIPHENYLBUTANAMIDE DERIVATIVES AND MEDICINES CONTAINING THE SAME

2,2-Diphenylbutanamide derivatives represented by the following formula (1): [wherein A represents -(CH2)n- (n is 1 or 2) or a methine (CH) group; when A is -CH2-, B represents a methine group or a nitrogen atom, with A and B forming a single bond; when A is -(CH2)2-, B represents a nitrogen atom, with A and B forming a single bond; when A is a methine group, B represents a quaternary carbon atom, with A and B forming a double bond; each of R1 and R2, which are identical to or different from each other, represents a hydrogen atom, a lower alkyl group, or a cycloalkyl group, or R1 and R2 may form a heterocyclic ring together with the adjacent nitrogen atom; and Ar represents an optionally substituted phenyl group, bicyclic aromatic ring, monocyclic heterocyclic ring, bicyclic heterocyclic ring, or fluorene group]; or salts of the derivatives. The derivatives or salts thereof exhibit excellent μ-opioid agonist activity and analgesic activity against neuropathic pain, and are useful as medicines such as peripheral analgesic drugs and neuropathic pain relieving drugs.