412303-22-1

Upstream product

• 331949-29-2 benzyl (2S)-N-tert-butoxycarbonyl-5-hydroxypyrrolidine-2-carboxylate 
• 113400-36-5 benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate 
• 100-39-0 benzyl bromide 
• 185142-15-8 (2S,5R)-N-(tert-butyloxycarbonyl)-5-tert-butylproline 
• 594-19-4 tert.-butyl lithium 
• 331949-31-6 benzyl (2S)-N-tert-butoxycarbonyl-5-methoxypyrrolidine-2-carboxylate 

Downstream Products

• 412303-26-5 N-(tert-butoxycarbonyl)-(S)-phenylalanyl-(2S,5R)-5-tert-butylproline benzyl ester 
• 412303-25-4 N-(tert-butoxycarbonyl)-(S)-leucyl-(2S,5R)-5-tert-butylproline benzyl ester 
• 412303-24-3 N-(tert-butoxycarbonyl)-(S)-alanyl-(2S,5R)-5-tert-butylproline benzyl ester 
• 224951-66-0 N-(tert-butyloxycarbonyl)-(2S)-phenylalanyl-(2S,5R)-5-tert-butylproline 

Relevant academic research and scientific papers

Effect of sequence on peptide geometry in 5-tert-butylprolyl type VI β-turn mimics

The influence of sequence on turn geometry was examined by incorporating (2S,5R)-5-tert-butylproline (5-tBuPro) into a series of dipeptides and tetrapeptides. (2S,5R)-5-tert-Butylproline and proline were respectively introduced at the C-termina

Improved synthesis of (2S,5S)-5-tert-butylproline

(2S,5S)-N-Boc-5-tert-butylproline (1) was synthesized by an improved procedure featuring the conversion of (2S)-1-tert-butyldimethylsiloxy-2-N-(PhF)amino-5-oxo-6,6-dimethylheptane (16) into its corresponding imino alcohol followed by directed hydride deli