412306-15-1

Basic information

• Product Name: Hydrazinecarbothioamide, 2-[1-(2-hydroxyphenyl)-3-phenyl-2-propenylidene]-
• CAS NO: 412306-15-1
• Molecular Formula: C16H15N3OS
• Molecular Weight: 297.381
• Mol File: 412306-15-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Hydrazinecarbothioamide, 2-[1-(2-hydroxyphenyl)-3-phenyl-2-propenylidene]-(CAS DataBase Reference)
• NIST Chemistry Reference: Hydrazinecarbothioamide, 2-[1-(2-hydroxyphenyl)-3-phenyl-2-propenylidene]-(412306-15-1)
• EPA Substance Registry System: Hydrazinecarbothioamide, 2-[1-(2-hydroxyphenyl)-3-phenyl-2-propenylidene]-(412306-15-1)

Safety Data

• Hazardous Substances Data: 412306-15-1(Hazardous Substances Data)

Upstream product

• 118-93-4 o-hydroxyacetophenone 
• 100-52-7 benzaldehyde 
• 79-19-6 thiosemicarbazide 
• 1214-47-7 1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one 

Relevant articles and documents

Microwave-assisted synthesis and tyrosinase inhibitory activity of chalcone derivatives

A series of chalcones and their derivatives were synthesized, and their inhibitory effects on the diphenolase activity of mushroom tyrosinase were evaluated. The results showed that some of the synthesized compounds exhibited significant inhibitory activity, and four compounds exhibited more potent tyrosinase inhibitory activity than the reference standard inhibitor kojic acid (5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one). Specifically, 1-(-1-(4-methoxyphen- yl)-3-phenylallylidene)thiosemicarbazide (18) exhibited the most potent tyrosinase inhibitory activity with IC50 value of 0.274 μm. The inhibition mechanism analysis of 1-(-1-(2,4-dihydroxyphenyl)-3-phenylallylidene) thiosemicarbazide (16) and 1-(-1-(4-methoxyphenyl)-3-phenylallylidene) thiosemicarbazide (18) demonstrated that the inhibitory effects of the two compounds on the tyrosinase were irreversible. Preliminary structure activity relationships' analysis suggested that further development of such compounds might be of interest.