412306-15-1Relevant academic research and scientific papers
Microwave-assisted synthesis and tyrosinase inhibitory activity of chalcone derivatives
Liu, Jinbing,Chen, Changhong,Wu, Fengyan,Zhao, Liangzhong
, p. 39 - 47 (2013/07/26)
A series of chalcones and their derivatives were synthesized, and their inhibitory effects on the diphenolase activity of mushroom tyrosinase were evaluated. The results showed that some of the synthesized compounds exhibited significant inhibitory activity, and four compounds exhibited more potent tyrosinase inhibitory activity than the reference standard inhibitor kojic acid (5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one). Specifically, 1-(-1-(4-methoxyphen- yl)-3-phenylallylidene)thiosemicarbazide (18) exhibited the most potent tyrosinase inhibitory activity with IC50 value of 0.274 μm. The inhibition mechanism analysis of 1-(-1-(2,4-dihydroxyphenyl)-3-phenylallylidene) thiosemicarbazide (16) and 1-(-1-(4-methoxyphenyl)-3-phenylallylidene) thiosemicarbazide (18) demonstrated that the inhibitory effects of the two compounds on the tyrosinase were irreversible. Preliminary structure activity relationships' analysis suggested that further development of such compounds might be of interest.
Studies on ruthenium(III) chalcone thiosemicarbazone complexes as catalysts for carbon-carbon coupling
Muthukumar,Sivakumar,Viswanathamurthi,Karvembu,Prabhakaran,Natarajan
experimental part, p. 296 - 306 (2010/09/10)
New six-coordinate ruthenium(III) complexes [RuX(EPh3)2(L)] (X = Cl or Br; E = P or As; L = chalcone thiosemicarbazone) have been prepared by reacting [RuX3(EPh3)3] (X = Cl or Br; E = P or As) with chalcone thiosemicarbazones in benzene under reflux. The new complexes have been characterized by analytical and spectroscopic (IR, electronic, mass, and EPR) data. The redox behavior of the complexes has also been studied. Based on the above data, an octahedral structure has been assigned for all the complexes. The new complexes exhibit catalytic activity for carbon-carbon coupling reactions.
