412339-43-6Relevant academic research and scientific papers
Preparation method of substituted 2, 3-phthalazinone compound
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Paragraph 0069; 0070, (2018/07/30)
The invention provides a preparation method of a substituted 2, 3-phthalazinone compound. The method includes the steps of: (1) adding substituted hydrazine and substituted o-carboxybenzaldehyde intoa reaction container, controlling the reaction temperature at 50DEG C-150DEG C, and carrying out thermal insulation reaction under mechanical mixing; and (2) carrying out TLC or gas phase monitoring reaction, at the end of the reaction, adding a precipitating agent into the reaction system, conducting stirring for 0.5-1.0h, and conducting standing and filtering to obtain a solid crystal, i.e. thesubstituted 2, 3-phthalazinone compound. Starting from cheap and easily available raw materials, the preparation method provided by the invention employs one-pot process for efficient preparation of aseries of highly bioactive substituted 2, 3-phthalazinone compounds with a yield of 90%-99% under a molten state. The method has the characteristics of wide substrate application range, no adding ofcatalyst, no use of solvent and mild conditions, the reaction time is shortened by 95% or more than that of the catalytic preparation method under the traditional solvent condition, and the product purity is very high.
Access to phthalazinones via palladium-catalyzed three-component cycloamino-carbonylation of 2-formylaryl tosylates, hydrazines and CO
Liu, Bin,Zhang, Chunlei,Zhou, Xigeng
, p. 8282 - 8286 (2016/12/02)
The palladium-catalyzed three-component cycloaminocarbonylation of 2-formylaryl tosylates with hydrazines and carbon monoxide has been established, which provides an efficient method for synthesis of substituted phthalazinones. In addition, by applying this protocol as the key step, Hydralazine can easily be synthesized in 65% yield.
Palladium-catalyzed phthalazinone synthesis using paraformaldehyde as carbon source
Wang, Huamin,Cai, Jinhui,Huang, Huawen,Deng, Guo-Jun
supporting information, p. 5324 - 5327 (2015/01/09)
A palladium-catalyzed one-pot synthesis of phthalazinones from 2-halomethyl benzoates, paraformaldehyde, and aryl hydrazines is described. Various substituted phthalazinones were selectively obtained in good yields using paraformaldehyde as the cheap carbon source (CH). (Chemical Equation Presented).
A novel method for the synthesis of 1(2H)-phthalazinones using silica-supported perchloric acid
Heravi, Majid M.,Baghernejad, Bita,Oskooie, Hossein A.
experimental part, p. 351 - 354 (2009/07/19)
A simple and efficient synthesis of 1(2H)-phthalazinone derivatives was achieved via reaction of phthalaldehydic acid and various phenyl hydrazines in acetonitrile using HClO4-SiO2 as a catalyst in very good yields.
