412355-81-8

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-Pyrimidinyl)-4-piperidinamine is used as an intermediate in the synthesis of pyrimidine-based drugs and other heterocyclic compounds for their therapeutic applications.
Used in Agrochemical Industry:
1-(2-Pyrimidinyl)-4-piperidinamine is used as a building block in the production of agrochemicals, contributing to the development of effective and safe products for agricultural use.
Used in Research and Development:
P-PDA is used as a chemical compound in research and development for its potential antileishmanial and antimicrobial properties, exploring its applications in the treatment of various diseases and infections.

InChI:InChI=1/C9H14N4/c10-8-2-6-13(7-3-8)9-11-4-1-5-12-9/h1,4-5,8H,2-3,6-7,10H2

Upstream product

• 73874-95-0 (piperidin-4-yl)carbamic acid tert-butyl ester 
• 1452394-23-8 2-(4-azidopiperidin-1-yl)pyrimidine 
• 180695-80-1 tert-butyl 4-azidopiperidine-1-carboxylate 

Downstream Products

• 1025392-74-8 (4-bromo-2-nitro-phenyl)-(1-pyrimidin-2-yl-piperidin-4-yl)-amine 
• 1033844-52-8 6-(2-hydroxyphenyl)-N-(1-pyrimidin-2-ylpiperidin-4-yl)nicotinamide 

Relevant academic research and scientific papers

TAM KINASE INHIBITORS

Described herein are compounds, methods of making such compounds, compositions (e.g., pharmaceutical compositions/medicaments) that include such compounds, and methods of using such compounds to treat diseases, such as cancer.

Disubstituted 1-aryl-4-aminopiperidine library synthesis using computational drug design and high-throughput batch and flow technologies

A platform that incorporates computational library design, parallel solution-phase synthesis, continuous flow hydrogenation, and automated high throughput purification and reformatting technologies was applied to the production of a 120-member library of 1-aryl-4-aminopiperidine analogues for drug discovery screening. The application described herein demonstrates the advantages of computational library design coupled with a flexible, modular approach to library synthesis. The enabling technologies described can be readily adopted by the traditional medicinal chemist without extensive training and lengthy process development times.

PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS

The application relates to compounds of Formula (Ia), and pharmaceutically acceptable salts, solvates, hydrates, geometrical isomers, tautomers, optical isomers and N-oxides thereof. The application also relates to pharmaceutical compositions comprising t

AMINE-LINKED MULTICYCLIC COMPOUNDS AS INHIBITORS OF THE PROLINE TRANSPORTER

This invention relates to multicyclic compounds, pharmaceutical compositions comprising them, and methods of their use.

Non-nucleoside reverse transcriptase inhibitors

The present invention provides for compounds useful for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein R1, R2, R3, R4, R5a, R5b, R6a, R6b and X are as herein defined. Also disclosed in the present invention are methods of treating an HIV infection with compounds defined herein and pharmaceutical compositions containing said compounds.

NEW COMPOUNDS

The present invention relates to new, potent DPP-IV enzyme inhibitors of the general formula (I), which contain fluorine atoms.

NITROGENOUS FIVE-MEMBERED RING COMPOUNDS

The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I] : wherein symbols in the formula have the following meanings;A: -CH2- or -S-,B: CH or N,R1: H, a lower alkyl group, etc.,X: a single bonding arm, -CO-, -Alk-CO-, -COCH2-, -Alk-O-, -O-CH2-, -SO2-, -S-, -COO-, -CON(R3)-, -Alk-CON(R3)-, -CON(R3)CH2-, -NHCH2-, etc.,R3: hydrogen atom or a lower alkyl group,Alk: a lower alkylene group, andR2: (1) a cyclic group which may be substituted, (2) a substituted amino group, etc., provided that when X is -CO-, then B is N, or a pharmaceutically acceptable salt thereof.