41242-95-9

Usage

Type

Derivative of quinoxalinone

Contains

Hydroxymethyl group

Potential applications

Pharmaceutical industry (drug development, therapeutic agents)

Importance

Hydroxymethyl group may impart desirable biological activities, making it of interest for further study and development

Value

Potentially valuable chemical compound for drug discovery and development

Upstream product

• 1222-71-5 3-(D_r-1t_F,2c_F,3r_F,4-tetrahydroxy-but-cat_F-yl)-1H-quinoxalin-2-one 
• 215191-49-4 2-phenyl-1’H,5H-spiro[oxazole-4,2’-quinoxalin]-3’(4’H)-one 

Relevant academic research and scientific papers

RING-opening reactions of 2-phenyl-1'H,5H-spiro-[oxazole-4,2'-quinoxalin]- 3'(4'H)-ones?

Several simple quinoxaline derivatives were prepared by ring-opening reactions of 2-phenyl-1'H,5H-spiro[oxazole-4,2'-quinoxalin]-3'(4'H)-one and its N-alkyl derivatives under various reaction conditions.

Oxidative removal of heterocyclic alkyl or sugar side chain by microwave: A simple step to xanthopterin, 6-formylpterin, and 3-hydroxymethyl-2(1H)- quinoxalinone

One-step microwave-assisted oxidative removal of 3-methyl and 3-sugar side chain in 2(lH)-quinoxalinone system by selenium dioxide and sodium periodate respectively resulting 2(1H)quinoxalinone has been reported. Similarly xanthopterin (as acetyl derivative 11) was isolated from selenium dioxide oxidation of 7-methylxanthopterin. In the absence of adjacent lactam moiety, sodium periodate efficiently oxidizes 2-acetylaminopterin tetrols 7 and 8 to 2-acetylamino-6-formylpterin (16) and the quinoxaline tetrols 9 and 10 respectively to quinoxaline aldehyde 17. However, all the compounds remained unchanged on refluxing with selenium dioxide. The new quinoxalone compounds 15 and 18 were simply synthesized by manganese dioxide oxidation of the completely unprotected 3-substituted sugar of 2(lH)-quinoxalinone 5 and quinoxaline 10 respectively under microwave condition. Copyright