215191-49-4

Upstream product

• 99074-27-8 2-benzoylamino-3-chloropropenoic acid 
• 95-54-5 1,2-diamino-benzene 
• 107872-68-4 2-benzoylamino-3-chloro-acrylic acid 

Downstream Products

• 1345700-39-1 4'-(2-hydroxyethyl)-2-phenyl-1'H,5H-spiro[oxazole-4,2'-quinoxalin]-3'(4'H)-one 
• 14003-34-0 3-methyl-2-oxo-1,2-dihydroquinoxaline 
• 55-21-0 benzamide 
• 34070-68-3 3,4-dihydro-3-methyl-1H-quinoxalin-2-one 
• 41242-95-9 3-(hydroxymethyl)quinoxalin-2(1H)-one 
• 613-92-3 N-hydroxybenzenecarboximidamide 
• 1454306-55-8 3-(benzoyloxymethyl)quinoxalin-2(1H)-one 

Relevant academic research and scientific papers

Synthesis of spiro-2-oxazolines

Several spiro-2-oxazolines were synthesized by treatment of 2-benzoylamino-3-chloropropenoic acid with a series of aromatic and heteroaromatic diamines. Alkylation of these compounds took place on the lactam nitrogen of the 3,4-dihydropyrazin-2(1H)-one part of the spiro systems.

Synthesis and alkylation of spiro-2-oxazolines containing fused 3,4-dihydropyrazin-2(1H)-ones

Spiro-2-oxazolines containing 3,4-dihydroquinoxalin-2(1H)-one, 3,4-dihydrobenzoquinoxalin-2(1H)-one, 1,2-dihydropyrido[2,3-b]pyrazin-3(4H)- one or 5,6-dihydropteridin-7(8H)-one moiety were prepared by heating of aromatic or heteroaromatic diamines with 2-benzoylamino-3-chloropropenoic acid in the presence of triethylamine. Treatment of spiro-2-oxazolines with MeI or EtBr using Bu4NHSO4 and K2CO3 introduced the methyl or ethyl group on the lactam nitrogen atom.