41248-13-9

Basic information

• Product Name: 1-Hydroxy-cyclobutanecarboxylic acid
• Synonyms: 1-Hydroxy-cyclobutanecarboxylic acid;1-hydroxycyclobutane-1-carboxylicacid
• CAS NO: 41248-13-9
• Molecular Formula: C₅H₈O₃
• Molecular Weight: 116.11522
• Product Categories: pharmacetical
• Mol File: 41248-13-9.mol

Chemical Properties

• Melting Point: 68 °C(Solv: benzene (71-43-2); ligroine (8032-32-4))
• Boiling Point: 120 °C
• Appearance: /
• Density: 1.476±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.05±0.20(Predicted)
• CAS DataBase Reference: 1-Hydroxy-cyclobutanecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Hydroxy-cyclobutanecarboxylic acid(41248-13-9)
• EPA Substance Registry System: 1-Hydroxy-cyclobutanecarboxylic acid(41248-13-9)

Safety Data

• Hazardous Substances Data: 41248-13-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Hydroxy-cyclobutanecarboxylic acid is used as a key intermediate in the synthesis of piperidines or piperidones substituted with urea and heteroaryl as FPR2 modulators. These FPR2 modulators have potential therapeutic applications in treating various medical conditions, such as inflammatory diseases and metabolic disorders, by modulating the activity of the formyl peptide receptor 2 (FPR2).

Physical Form

Solid

Upstream product

• 1191-95-3 cyclobutanone 
• 74-90-8 hydrogen cyanide 
• 32122-23-9 α-bromocyclobutanecarboxylic acid 
• 3721-95-7 Cyclobutanecarboxylic acid 
• 3008-40-0 cyclopentane-1,2-dione 
• 55767-58-3 1-hydroxycyclobutane-1-carbonitrile 
• 22264-50-2 1-aminocyclobutane-1-carboxylic acid 

Downstream Products

• 1380111-08-9 C₂₀H₁₇NO₅ 
• 1380111-09-0 C₁₂H₁₅NO₃ 
• 1380111-14-7 C₄₇H₅₀N₈O₁₁S 
• 1380111-13-6 C₂₆H₃₂N₆O₇S 
• 1380111-12-5 C₂₆H₃₀N₈O₇S 
• 1380111-11-4 C₃₃H₃₇N₅O₁₀S₂ 

Relevant articles and documents

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Provided herein are compounds according to formula (I): Provided herein is also a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, and a method for providing anesthesia in a subject by administering such a pharmaceutical composition.

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Regioselective synthesis of α,α-dialkylcyclopentanones from 1-hydroxycyclobutanecarboxylic acid or from O-protected cyclobutanone cyanohydrin

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