41248-16-2

Upstream product

• 591-24-2 3-Methylcyclohexanone 
• 861316-04-3 1-benzoyloxy-3-methyl-cyclohexanecarboxylic acid anilide 
• 854447-40-8 1-hydroxy-3-methyl-cyclohexanecarboxylic acid anilide 
• 933-42-6 1-hydroxy-3-methyl-cyclohexanecarbonitrile 
• 101252-18-0 1-Hydroxy-3-methylcyclohexylcarboxamid 

Downstream Products

• 13828-32-5 m-2-menthene 
• 91761-52-3 1-methyl-3-isopropyl-cyclohexanol-⁽³⁾ 
• 15466-94-1 cis-1,3-dimethylcyclohexanol 
• 101869-71-0 (+/-)-1-hydroxymethyl-cis-3-methylcyclohexanol 
• 15466-94-1 cis-1,3-Dimethylcyclohexan-1-ol 
• 101869-71-0 (+/-)-1-hydroxymethyl-trans-3-methylcyclohexanol 
• 103260-32-8 (+/-)-1-hydroxy-3c-methyl-cyclohexane-r-carboxylic acid methyl ester 
• 103260-32-8 (+/-)-1-hydroxy-3t-methyl-cyclohexane-r-carboxylic acid methyl ester 
• 591-24-2 3-Methylcyclohexanone 

Relevant academic research and scientific papers

Lactone Formation in Superacidic Media

The reaction of substituted 1-hydroxycyclohexanecarboxylic acids in fluorosulphuric acid has been studied.Cyclisation takes place around 0 deg C, accompanied by rearrangement in appropriate cases, yielding the thermodynamically stable lactone or mixture of lactones.An unexpected feature of these reactions is that the carboxy-substituted cyclohexyl carbocation does not undergo ring contraction, unlike the unsubstituted cyclohexyl carbocation, although the cycloheptyl system contracts to cyclohexyl.We suggest that the cyclohexyl carbocation is strongly stabilised by carboxyl substitution, as a result of through-space interaction between the carboxyl oxygen atom and the carbocation centre.

2-Amino-5-spiro substituted oxazoline-4-one compounds

A novel series of 2-amino-5-spiro substituted oxazolin-4-ones and intermediates for making said compounds. These compounds are prepared by first converting the appropriately substituted cycloketone to the corresponding cyclocyanohydrin; converting this co