41282-24-0

Upstream product

• 22483-09-6 2,2-dimethoxyethylamine 
• 819793-73-2 7-chloro-2-(N-nitrosomethylamino)-5-phenyl-3H-1,4-benzodiazepine 
• 59639-28-0 2-[1-(2-benzoyl-4-chloro-phenyl)-1H-imidazol-2-ylmethyl]-phthalimide 

Downstream Products

• 121899-13-6 2-(8-Chloro-6-phenyl-3,5,10b-triaza-benzo[e]azulen-3-yl)-ethanol 
• 121899-15-8 2-(8-Chloro-6-phenyl-4H-3,5,10b-triaza-benzo[e]azulen-4-yl)-ethanol 
• 121899-14-7 2-(8-Chloro-6-phenyl-6H-3,5,10b-triaza-benzo[e]azulen-6-yl)-ethanol 
• 76879-45-3 8-chloro-1-[(dimethylamino)methyl]-6-(o-chlorophenyl)-4H-imidazo-[1,2-a][1,4]benzodiazepine 
• 121899-05-6 (8-Chloro-6-phenyl-4H-3,5,10b-triaza-benzo[e]azulen-4-ylmethyl)-dimethyl-amine 
• 121899-06-7 (8-Chloro-4-dimethylaminomethyl-6-phenyl-4H-3,5,10b-triaza-benzo[e]azulen-1-ylmethyl)-dimethyl-amine 
• 57963-20-9 8-chloro-1-[(dimethylamino)methyl]-6-phenyl-4H-imidazo[1,2-a][1,4]benzodiazepine 

Relevant academic research and scientific papers

1,4-Benzodiazepine N-nitrosoamidines: Useful intermediates in the synthesis of tricyclic benzodiazepines

1,4-Benzodiazepine N-nitrosoamidines have been used as scaffolds for the preparation of different tricyclic derivatives. Replacement of the N-nitrosoamidine moiety through treatment with the nucleophiles acetylhydrazine, aminoacetaldehyde dimethylacetal and 1-amino-2-propanol, followed by an acid-catalyzed cyclization step, afforded triazolo and imidazobenzodiazepines 1, 6, and 7, respectively, in good yields. When acetylhydrazine is used as a nucleophile, the overall process provides an alternative route to alprazolam (1b) and triazolam (1c), respectively.

2-(Imidazol-1-yl)benzophenones

Compounds of formula II SPC1 and its phthalimide derivative III: SPC2 wherein R0 and R1 are hydrogen or alkyl of 1 to 3 carbon atoms, inclusive; wherein R2 is hydrogen, chloro, fluoro, or trifluoromethyl; wherein R3/

2-(2-Alkynylamino)-3H-1,4-benzodiazepines

Novel 6-substituted 4H-imidazo[1,2-a][1,4]benzodiazepines, the intermediate 5-substituted-2-(2-alkynylamino)-3H-1,4-benzodiazepines, pharmacologically acceptable acid addition salts thereof, and processes for their production. The compounds of this invention and the pharmacologically acceptable acid addition salts thereof are central nervous system depressants. They are useful as sedatives, hypnotics, tranquilizers, muscle relaxants and anticonvulsants, and also as feed additives for increasing growth rate and feed efficiency of livestock and poultry, milk production in the mammalian species and egg production in avian species.