41285-62-5

Upstream product

• 19172-47-5 Lawessons reagent 
• 30839-20-4 1,4-bis(4-methoxyphenyl)-2,3-diphenylbutane-1,4-dione 
• 83125-18-2 2,5-dibromo-3,4-diphenylthiophene 
• 5720-07-0 4-methoxyphenylboronic acid 
• 108-86-1 bromobenzene 
• 1025014-17-8 2,5-bis(4-methoxyphenyl)-3-thiophenecarboxylic acid 
• 70-11-1 α-bromoacetophenone 
• 100989-94-4 3-(2-chlorophenyl)-4-phenylthiophene 
• 2461-80-5 diphenacyl sulfide 

Relevant academic research and scientific papers

Palladium-catalyzed perarylation of 3-thiophene- and 3-furancarboxylic acids accompanied by C-H bond cleavage and decarboxylation

3-Thiophene- and 3-furancarboxylic acids efficiently undergo perarylation accompanied by cleavage of the three C-H bonds and decarboxylation upon treatment with excess aryl bromides in the presence of a palladium catalyst to give the corresponding tetraarylated products in good yields.

One-pot oxidation and bromination of 3,4-diaryl-2,5-dihydrothiophenes using Br2: Synthesis and application of 3,4-diaryl-2,5-dibromothiophenes

(Chemical Equation Presented) A class of 3,4-diaryl-2,5-dibromothiophenes (1b-5b) was synthesized by a one-pot reaction of 3,4-diaryl-2,5- dihydrothiophenes with Br2 reagent in excellent yield (83-92%). It was found that Br2 performed a double function (oxidation and bromination) during the conversion of 3,4-diaryl-2,5-dihydrothiophenes to 3,4-diaryl-2,5-dibromothiophenes. The application of 3,4-diaryl-2,5- dibromothiophenes used as building blocks was also investigated. Employing 3,4-diphenyl-2,5-dibromothiophene (1b) as a template, a class of 2,3,4,5-tetraarylthiophenes was prepared by the Suzuki coupling reaction. This provided a new and simple approach to the preparation of 2,3,4,5- tetraarylthiophenes.

Reaction of 2,4-Bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulphide with Substituted Butane-1,4-diones: Part II - Novel Synthesis of Substituted Thiophenes and Furans

The reaction of substituted butane-1,4-diones (2) with 2,4-bis(4-methoxyphenyl)1,3,2,4-dithiadiphosphetane-2,4-disulphides (1; Lawesson reagent) has been investigated.While the reaction of 1,2-diacylethane (2k) with 1 leads exclusively to the formation of the corresponding 2,5-disubstituted thiophene (4k) in excellent yield, the interaction of tri- and tetrasubstituted butane-1,4-diones (2a-j) with 1 under identical conditions invariably results in the formation of a mixture of the corresponding thiophenes (4) and furans (3) in varying proportions.The identity of 3 and 4 and also their molar percentages in the product mixtures have been established by GLC and PMR spectral analyses.