412923-59-2Relevant articles and documents
Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment
Xie, Jingjing,Si, Xiaojia,Gu, Shoulai,Wang, Mingliang,Shen, Jian,Li, Haoyan,Li, Dan,Fang, Yanjia,Liu, Cong,Zhu, Jidong
, p. 10205 - 10219 (2017)
SHP2, a cytoplasmic protein-tyrosine phosphatase encoded by the PTPN11 gene, is involved in multiple cell signaling processes including Ras/MAPK and Hippo/YAP pathways. SHP2 has been shown to contribute to the progression of a number of cancer types inclu