19339-62-9

Usage

Uses

Used in Organic Synthesis:
2-NAPHTHOYLMETHYL THIOCYANATE is used as a reagent for the preparation of thiosemicarbazones, which are important intermediates in the synthesis of various organic compounds.
Used in Pharmaceutical and Agricultural Industries:
2-NAPHTHOYLMETHYL THIOCYANATE serves as a starting material for the synthesis of other organic compounds with potential pharmaceutical or agricultural applications, highlighting its versatility in chemical research and development.
Used in Research and Development:
2-NAPHTHOYLMETHYL THIOCYANATE has been studied for its potential biological activity, indicating its possible use in the discovery of new therapeutic agents or agrochemicals. However, its physiological effects and potential hazards are not well documented, necessitating further research to fully understand its implications and safety profile.

InChI:InChI=1/C13H9NOS/c14-9-16-8-13(15)12-6-5-10-3-1-2-4-11(10)7-12/h1-7H,8H2

Upstream product

• 540-72-7 sodium thiocyanide 
• 333-20-0 potassium thioacyanate 
• 827-54-3 2-naphthylethylene 
• 1147550-11-5 ammonium thiocyanate 
• 613-54-7 2-Bromo-2'-acetonaphthone 
• 93-08-3 methyl 2-naphthyl ketone 

Downstream Products

• 412923-59-2 2-bromo-4-(naphthalen-2-yl)thiazole 

Relevant academic research and scientific papers

Iodine/MeOH as a novel and versatile reagent system for the synthesis of α-ketothiocyanates

Ketones possessing α-hydrogens undergo smooth thiocyanation with ammonium thiocyanate in the presence of molecular iodine in refluxing methanol to produce the corresponding α-ketothiocyanates in excellent yields with high selectivity. The use of iodine ma

A simple and efficient thiocyanation of indoles, anilines and keto compounds catalyzed by a polystyrene resin amberlyst-15

Thiocyanation of various aromatic, heteroaromatic and enolizable ketone compounds has been achieved with ammonium thiocyanate in presence of polystyrene cation exchange resin, Amberlyst-15. All the reactions were carried out in acetonitrile at room temper

Visible-light-promoted thiocyanation of sp2C-H bonds over heterogeneous graphitic carbon nitrides

Mesoporous graphitic carbon nitride (mpg-C3N4) has been developed as a metal-free heterogeneous photocatalyst for thiocyanation transformations. The reaction proceeds efficiently by utilizing air as a green oxidant under mild reaction conditions, which affords SCN-containing compounds in moderate to excellent yields. Meanwhile, the practicality of this protocol is further demonstrated by the reusability of the mpg-C3N4photocatalyst and the scaled-up reaction. Furthermore, detailed mechanistic studies clearly demonstrate the role of oxygen.

Visible-Light-Promoted Difunctionalization of Olefins Leading to α-Thiocyanato Ketones

A simple and convenient visible-light-induced difunctionalization of alkenes with ammonium thiocyanate and dioxygen has been developed at room temperature. A series of α-thiocyanato ketones could be easily and efficiently obtained in moderate to good yields through the formation of C-S and C=O bonds simply by using nontoxic and inexpensive Na 2 -Eosin Y as a photocatalyst.

One-pot synthesis of (ethoxycarbonyl)difluoromethylthioethers from thiocyanate sodium and ethyl 2-(trimethylsilyl)-2,2-difluoroacetate (TMS-CF2CO2Et)

An efficient one-pot cascade methodology for the synthesis of (ethoxycarbonyl)difluoromethyl thioethers is described. Benzyl, allyl, alkyl halides or diazonium salts as the starting materials together with thiocyanate sodium and TMS-CF2CO2Et in the presence of CsF or NaOAc afford a variety of the fluoroalkylthiolated products in moderate to good yields.

Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment

SHP2, a cytoplasmic protein-tyrosine phosphatase encoded by the PTPN11 gene, is involved in multiple cell signaling processes including Ras/MAPK and Hippo/YAP pathways. SHP2 has been shown to contribute to the progression of a number of cancer types inclu

Synthesis of ionic liquid-supported hypervalent iodine reagent and its application as a 'catch and release' reagent for α-substituted acetophenones

A novel imidazolium-based ionic liquid-supported hypervalent iodine reagent has been synthesized and employed for a 'catch and release' strategy with substituted acetophenones to generate various α-substituted acetophenones in good to excellent yields. The use of an ionic liquid-supported hypervalent iodine reagent avoids chromatographic separation for the purification of α-substituted acetophenones and thus makes the method greener.

A convenient, rapid, and general synthesis of α-oxo thiocyanates using clay supported ammonium thiocyanate

A very rapid, convenient, and general method for the synthesis of α-oxo thiocyanates has been described by using clay supported ammonium thiocyanate. The procedure avoids the use of additional catalyst, solvent, aqueous work-up and the yields are high. Moreover, the method is applicable for a variety of aryl, heteroaryl, alkyl α-halo carbonyls, β-keto tosylates, α-halo β-dicarbonyl, α-tosyl, β-dicarbonyl, alkyl halide, and alkyl tosylates.

Iron(III) chloride as mild and efficient reagent for the α-thiocyanation of ketones: An expedient synthesis of α-oxo thiocyanates

A simple and efficient method for the α-thiocyanation of ketones has been developed; anhydrous iron(III) chloride is used under mild conditions to produce αoxo thiocyanates in good to high yields and with high selectivity. The use of inexpensive and readi