41303-46-2

Basic information

• Product Name: 6-(3,4-dimethoxyphenyl)-7,8-dihydronaphtho[2,3-d][1,3]dioxol-5(6H)-one
• CAS NO: 41303-46-2
• Molecular Formula: C₁₉H₁₈O₅
• Molecular Weight: 326.3432
• Mol File: 41303-46-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 505°C at 760 mmHg
• Flash Point: 224.1°C
• Density: 1.274g/cm³
• Vapor Pressure: 2.53E-10mmHg at 25°C
• Refractive Index: 1.595
• CAS DataBase Reference: 6-(3,4-dimethoxyphenyl)-7,8-dihydronaphtho[2,3-d][1,3]dioxol-5(6H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(3,4-dimethoxyphenyl)-7,8-dihydronaphtho[2,3-d][1,3]dioxol-5(6H)-one(41303-46-2)
• EPA Substance Registry System: 6-(3,4-dimethoxyphenyl)-7,8-dihydronaphtho[2,3-d][1,3]dioxol-5(6H)-one(41303-46-2)

Safety Data

• Hazardous Substances Data: 41303-46-2(Hazardous Substances Data)

Upstream product

• 77784-64-6 Naphtho<2,3-d>-1,3-dioxole-5-ol 
• 122775-35-3 3,4-Dimethoxyphenylboronic acid 
• 1008303-50-1 4,4-ethylenedioxy-6,7-methylenedioxy-1-oxo-1,4-dihydronaphthalene 
• 1008303-68-1 C₂₁H₂₁ClO₆ 
• 1008303-67-0 (1R,3R)-3-(3,4-dimethoxyphenyl)-4,4-ethylenedioxy-1-hydroxy-6,7-methylenedioxy-1,2,3,4-tetrahydronaphthalene 
• 1008303-61-4 (R)-3-(3,4-dimethoxyphenyl)-4,4-ethylenedioxy-6,7-methylenedioxy-1-oxo-1,2,3,4-tetrahydronaphthalene 
• 1008303-69-2 (R)-2-(3,4-dimethoxyphenyl)-1,1-ethylenedioxy-6,7-methylenedioxy-1,2,3,4-tetrahydronaphthalene 
• 88775-35-3 2-(3,4-dimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)butyramide 
• 88775-39-7 2-(3,4-dimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxobutyramide 
• 41303-68-8 2-(3,4-dimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxobutyric acid 
• 88775-45-5 (E)-1-(benzo[d][1,3]dioxol-5-yl)-3-(3,4-dimethoxyphenyl)-2-propen-1-one 
• 6329-73-3 1-benzo[1,3]dioxol-5-yl-ethanol 
• 3162-29-6 1-(benzo[d][1,3]dioxol-6-yl)ethanone 
• 120-57-0 piperonal 

Downstream Products

• 54785-15-8 6-(3,4-dimethoxy-phenyl)-7,8-dihydro-6H-naphtho[2,3-d][1,3]dioxol-5-one O-acetyl-oxime 
• 105594-68-1 cis-2-(3,4-dimethoxyphenyl)-1-(N-methylacetamido)-6,7-methylenedioxy-1,2,3,4-tetrahydronaphthalene 
• 105594-85-2 cis-2-(3,4-dimethoxyphenyl)-6,7-methylenedioxy-1-(N-methylformamido)-1,2,3,4-tetrahydronaphthalene 
• 105594-69-2 2-(3,4-dimethoxyphenyl)-1-(N-methylacetamido)-6,7-methylenedioxynaphthalene 
• 105594-89-6 2-(3,4-dimethoxyphenyl)-6,7-methylenedioxy-1-(N-methylformamido)naphthalene 
• 105594-81-8 cis-2-(3,4-dimethoxyphenyl)-N-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydro-1-naphthylamine 
• 88114-55-0 2-(3,4-dimethoxyphenyl)-6-hydroxy-7-methoxy-1-(N-methylformamido)naphthalene 
• 52259-64-0 fagaronine 
• 13063-04-2 nitidine chloride 
• 111354-96-2 7-(3,4-dimethoxy-phenyl)-5,6-dihydro-naphtho[2,3-d][1,3]dioxole 
• 41303-70-2 N-[6-(3,4-dimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxol-5-yl]-formamide 
• 41349-30-8 2-(3,4-dimethoxyphenyl)-6,7-methylenedioxy-3,4-dihydronaphthalene-1(2H)-oneoxime 

Relevant articles and documents

Asymmetric 1,4-addition of organoboron reagents to quinone monoketals catalyzed by a chiral diene/rhodium complex: A new synthetic route to enantioenriched 2-aryltetralones

A novel synthetic approach to 2-aryltetra-lones with high ee has been developed through asymmetric 1,4-addition of arylboronic acids to naphthoquinone monoketals catalyzed by a rhodium complex with the (R,R)-Ph-bod* ligand. The asymmetric addition proceed

Studies on the chemical constituents of rutaceous plants. L. Development of a versatile method for the synthesis of antitumor-active benzo[c]phenanthridine alkaloids. (2). Preparation of 2-aryl-1-tetralone derivatives

The synthetic pathway from 2,4-bisaryl-4-oxobutyramide (3) to 2-aryl-1-tetralone (4), which is the key intermediate in the Robinson synthesis of antitumor-active benzo[c]phenanthridine alkaloids was improved. Treatment of the model keto-amide (3a) under the reported basic conditions gave γ-keto-α,β-unsaturated acid (9) and degradation products. Reduction of the 2,4-bisaryl-4-oxobutyramide (3) with sodium borohydride gave 2,4-bisaryl-4-hydroxybutyramide (16) which could easily be hydrogenolyzed to give 2,4-bisarylbutyramide (15). However, this transformation also tended to give a γ-lactam derivative (17), unfortunately. We succeeded in the direct hydrogenolysis of the 2,4-bisaryl-4-oxobutyramide (3) to the 2,4-bisarylbutyramide (15), which could be hydrolyzed to the corresponding acid (5) without difficulty. The direct hydrolysis of the 2,4-bisaryl-4-oxobutyronitrile (2) to the 2,4-bisaryl-4-oxobutyric acid (6) as reported by Cheng et al. was also examined. Ten 2-aryl-1-tetralones (4) required as starting materials for syntheses of various benzo[c]phenanthridine alkaloids were prepared.