52259-64-0

Upstream product

• 56516-91-7 2-isopropoxy-3,8,9-trimethoxy-5-methylbenzophenanthridininium chloride 
• 88114-49-2 dihydrofagaronine 
• 52259-71-9 O-isopropylnorfagaronine 
• 77-78-1 dimethyl sulfate 
• 470461-22-4 [(Z)-2-(3,4-Dimethoxy-phenyl)-1-(4-isopropoxy-5-methoxy-2-vinyl-phenyl)-vinyl]-methyl-carbamic acid ethyl ester 
• 470461-24-6 3-[2-(2,2-dimethoxy-ethyl)-4-isopropoxy-5-methoxy-phenyl]-6,7-dimethoxy-2-methyl-2H-isoquinolin-1-one 
• 88114-45-8 3'-isopropoxy-3,4,4'-trimethoxychalcone 
• 88114-52-7 [2-(3,4-Dimethoxy-phenyl)-6-isopropoxy-7-methoxy-3,4-dihydro-2H-naphthalen-(1Z)-ylidene]-methyl-amine 
• 88114-54-9 2-(3,4-dimethoxyphenyl)-6-isopropoxy-7-methoxy-1-(N-methylformamido)naphthalene 
• 88114-47-0 2-(3,4-dimethoxyphenyl)-4-(3-isopropoxy-4-methoxyphenyl)-4-oxobutyric acid 
• 88114-46-9 2-(3,4-dimethoxyphenyl)-4-(3-isopropoxy-4-methoxyphenyl)-4-oxobutyronitrile 
• 88114-56-1 cis-2-(3,4-dimethoxyphenyl)-6-isopropoxy-7-methoxy-1-(N-methyl-formamido)-1,2,3,4-tetrahydronaphthalene 
• 113964-91-3 2-(3,4-dimethoxyphenyl)-6-isopropyloxy-7-methoxy-3,4-dihydronaphthalen-1(2H)-one 
• 113964-89-9 2-(3,4-dimethoxyphenyl)-4-(3'-isopropyloxy-4'-methoxy)phenyl butyric acid 

Relevant academic research and scientific papers

Synthesis of an Oligonucleotide-Intercalator Conjugate in Which the Linker Chain is Attached Via the Phenolic Hydroxyl Group of Fagaronine

A synthesis of an antisense oligonucleotide bound covalently to the intercalator fagaronine has been performed.The conjugate is more potent as an inhibitor of HIV reverse transcriptase than the parent oligonucleotide TCAGTGGTp, and it also binds more strongly to a complementary RNA sequence. Key Words: Antisense; oligonucleotide-intercalator conjugate, benzophenanthridine, fagaronine

Short synthesis and antimalarial activity of fagaronine

Herein, we report a new synthesis of fagaronine 1, inspired by the synthesis reported by Luo for nornitidine. The in vitro biological activity of fagaronine against malaria on several chloroquine-sensitive and resistant Plasmodium falciparum strains was c

A new route to 3-(2-vinylphenyl)-2-methyl-2H-isoquinolin-1-ones and benzo[c]phenanthridines: Total synthesis of fagaronine

Treatment of N-carbethoxy-1-benzylideneisoquinolines with LDA gives N-ethoxycarbonyl-1-amino-1-(2-vinylphenyl)-2-phenylethylenes, which can be transformed into 3-(2-vinylphenyl)-2-methyl-2H-isoquinolin-1-ones by Bischler-Napieralski reactions, and thence

Synthesis and cytotoxic activities of a new benzo[c]phenanthridine alkaloid, 7-hydroxynitidine, and some 9-oxygenated benzo[c]phenanthridine derivatives.

[formula: see text] A new benzo[c]phenanthridine alkaloid, 7-hydroxynitidine, was synthesized by a novel synthetic procedure. The cytotoxic activity of this compound against HeLa S3 cells was strong, but not greater than those of its mother compounds, nitidine and NK109. We also synthesized other 9-oxygenated benzo[c]phenanthridine alkaloids, 7-methoxynitidine, 9-demethylnitidine, nitidine, and fagaronine, and tested their cytotoxic activities. These results suggest that the 7-hydroxy group enhances antitumor activity and an 8- or 9-hydroxy group weakens this activity.

High-yielding total synthesis of fagaronine chloride

A versatile method for the synthesis of the benzophenanthridine nucleus was developed and applied to the preparation of fagaronine chloride.This method provided an overall yield of 14percent, superior to other existing strategies, from a linear route c

SYNTHESIS OF FAGARONINE

Alkaloids fagaronine (I), dihydrofagaronine (XXV) and oxyfagaronine (XXVI) were synthesized from 2,3-dihydroxynaphthalene (II) and 2-bromo-4,5-dimethoxybenzaldehyde (XI), the key synthetic steps being the preparation of 2-hydroxy-3-methoxy-5-nitronaphthal

Studies on the Chemical Constituents of Rutaceous Plants. Part 62. Efficient Synthesis of Fagaronine, a Phenolic Benzophenanthridine Alkaloid with Antileukaemic Activity

Fagarinone (2), an antileukaemic hydroxybenzophenanthridine alkaloid, has been synthesized from the chalcone (4a) according to the synthetic sequence (Schemes 1-4).During the synthesis, the hydroxy group was protected in the form of its isopropoxy deri

TRANSFORMATION OF PROTOBERBERINES INTO BENZOPHENANTHRIDINES A NOVEL AND EFFICIENT SYNTHESIS OF ANTITUMOR BENZOPHENANTHRIDINE ALKALOIDS, FAGARONINE AND NITIDINE

Antileukemic benzophenanthridine alkaloids, fagaronine (1a) and nitidine (1c) were synthesized from the corresponding protoberberines through C6-N bond fission and subsequent cyclization between C6 and C13 position of the protoberberines.