413194-08-8

Upstream product

• 413192-98-0 2-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxy)-4-methyl-hex-4-en-3-ol 
• 5416-93-3 4-Methoxyphenyl isocyanate 
• 413193-02-9 2-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxy)-4-methyl-hex-4-en-3-ol 
• 151950-84-4 (Z)-tert-butyl((3-iodobut-2-en-1-yl)oxy)diphenylsilane 
• 152230-92-7 (-)-(S)-2-(t-Butyldimethylsilyl)-1-propanal 

Downstream Products

• 293294-24-3 (4-Methoxy-phenyl)-carbamic acid (Z)-(S)-4-hydroxy-1-((S)-1-hydroxy-ethyl)-2-methyl-but-2-enyl ester 
• 293294-27-6 (3aS,4S,6S,7aS)-6-(4-Methoxy-benzyloxy)-1-(4-methoxy-phenyl)-4,7a-dimethyl-hexahydro-pyrano[4,3-d]oxazol-2-one 
• 293294-26-5 (4-Methoxy-phenyl)-carbamic acid (2S,3S,6S)-6-(4-methoxy-benzyloxy)-2,4-dimethyl-3,6-dihydro-2H-pyran-3-yl ester 

Relevant academic research and scientific papers

Iodine(V) reagents in organic synthesis. Part 3. New routes to heterocyclic compounds via o-iodoxybenzoic acid-mediated cyclizations: Generality, scope, and mechanism

The discovery and development of the o-iodoxybenzoic acid (IBX) reaction with certain unsaturated N-aryl amides (anilides) to form heterocycles are described. The application of the method to the synthesis of δ-lactams, cyclic urethanes, hydroxy amines, and amino sugars among other important building blocks and intermediates is detailed. In addition to the generality and scope of this cyclization reaction, this article describes a number of mechanistic investigations suggesting a single electron transfer from the anilide functionality to IBX and implicating a radical-based mechanism for the reaction.