41330-49-8

Basic information

• Product Name: 3-CHLORO-1H-INDAZOL-5-AMINE
• Synonyms: 5-AMINO-3-CHLORO (1H)INDAZOLE;3-CHLORO-1H-INDAZOL-5-AMINE;5-AMINO-3-CHLOROINDAZOLE;3-Chloro-1H-indazol-5-amine ,97%;3-Chloro-1H-indazol-5-ylaMine;3-chloro-2H-indazol-5-amine
• CAS NO: 41330-49-8
• Molecular Formula: C₇H₆ClN₃
• Molecular Weight: 167.6
• Mol File: 41330-49-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 219.4°C at 760 mmHg
• Flash Point: 86.5°C
• Appearance: /
• Density: 1.533g/cm³
• Vapor Pressure: 0.119mmHg at 25°C
• Refractive Index: 1.777
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 12.45±0.40(Predicted)
• CAS DataBase Reference: 3-CHLORO-1H-INDAZOL-5-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-1H-INDAZOL-5-AMINE(41330-49-8)
• EPA Substance Registry System: 3-CHLORO-1H-INDAZOL-5-AMINE(41330-49-8)

Safety Data

• Statements: 20/21/22
• Safety Statements: 36/37
• Hazardous Substances Data: 41330-49-8(Hazardous Substances Data)

Usage

Chemical Properties

Red solid

InChI:InChI=1/C7H6ClN3/c8-7-5-3-4(9)1-2-6(5)10-11-7/h1-3H,9H2,(H,10,11)

Upstream product

• 4812-45-7 3-chloro-5-nitro-1H-indazole 
• 99-52-5 2-methyl-4-nitro-benzenamine 
• 19335-11-6 1H-indazol-5-ylamine 
• 5401-94-5 5-nitroindazole 

Downstream Products

• 49820-94-2 2-(3-chloro-1⁽²⁾H-indazol-5-ylamino)-benzoic acid 
• 599183-07-0 N-(3-chloro-1H-indazol-5-yl)-3-fluorobenzenesulfonamide 
• 599183-05-8 N-(3-chloro-1H-indazol-5-yl)-2-methylsulfonylbenzenesulfonamide 
• 599183-06-9 N-(3-chloro-1H-indazol-5-yl)-3,4-dichlorobenzenesulfonamide 

Relevant articles and documents

THERAPEUTIC INDAZOLES

The invention provides compounds of formula (I): and salts thereof wherein R1-R5 have any of the meanings described in the specification. The compounds are useful for treating bacterial infections (e.g. tuberculosis).

SUBSTITUTED OXOPYRIDINE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF CARDIOVASCULAR DISORDERS

The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.

Structure-Based Design, Synthesis, and Antimicrobial Activity of Indazole-Derived SAH/MTA Nucleosidase Inhibitors

The structure-based design, synthesis, and biological activity of a novel indazole-containing inhibitor series for S-adenosyl homocysteine/methylthioadenosine (SAH/MTA) nucleosidase are described. Use of 5-aminoindazole as the core scaffold provided a structure-guided series of low nanomolar inhibitors with broad-spectrum antimicrobial activity. The implementation of structure-based methodologies provided a 6000-fold increase in potency over a short timeline (several months) and an economy of synthesized compounds.