4812-45-7Relevant articles and documents
THERAPEUTIC INDAZOLES
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Page/Page column 38, (2019/03/17)
The invention provides compounds of formula (I): and salts thereof wherein R1-R5 have any of the meanings described in the specification. The compounds are useful for treating bacterial infections (e.g. tuberculosis).
Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor
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Page/Page column 48, (2010/02/15)
The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.
Structure-Based Design, Synthesis, and Antimicrobial Activity of Indazole-Derived SAH/MTA Nucleosidase Inhibitors
Li, Xiaoming,Chu, Sam,Feher, Victoria A.,Khalili, Mitra,Nie, Zhe,Margosiak, Stephen,Nikulin, Victor,Levin, James,Sprankle, Kelly G.,Tedder, Martina E.,Almassy, Robert,Appelt, Krzysztof,Yager, Kraig M.
, p. 5663 - 5673 (2007/10/03)
The structure-based design, synthesis, and biological activity of a novel indazole-containing inhibitor series for S-adenosyl homocysteine/methylthioadenosine (SAH/MTA) nucleosidase are described. Use of 5-aminoindazole as the core scaffold provided a structure-guided series of low nanomolar inhibitors with broad-spectrum antimicrobial activity. The implementation of structure-based methodologies provided a 6000-fold increase in potency over a short timeline (several months) and an economy of synthesized compounds.