4812-45-7

Usage

Chemical Properties

Yellow solid

InChI:InChI=1/C7H4ClN3O2/c8-7-5-3-4(11(12)13)1-2-6(5)9-10-7/h1-3H,(H,9,10)

Upstream product

• 61346-19-8 5-nitroindazolin-3-one 
• 7719-12-2 phosphorus trichloride 
• 128-09-6 N-chloro-succinimide 
• 5401-94-5 5-nitroindazole 
• 99-52-5 2-methyl-4-nitro-benzenamine 

Downstream Products

• 105126-48-5 3-Chloro-5-nitro-indazole-1-carboxylic acid (4-chloro-phenyl)-amide 
• 141278-23-1 3-Chlor-1-(2,3-epoxypropyl)-5-nitroindazol 
• 141278-22-0 3-Chlor-1-(3-chlor-2-hydroxypropyl)-5-nitroindazol 
• 41330-49-8 5-amino-3-chloro-1H-indazole 
• 854923-13-0 3-chloro-5-nitro-1-(2-pyrrolidin-1-yl-ethyl)-1H-indazole 

Relevant academic research and scientific papers

THERAPEUTIC INDAZOLES

The invention provides compounds of formula (I): and salts thereof wherein R1-R5 have any of the meanings described in the specification. The compounds are useful for treating bacterial infections (e.g. tuberculosis).

Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor

The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.

Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor

The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.

Indazole compounds useful as protein kinase inhibitors

The present invention provides compounds of formula I: or a pharmaceutically acceptable derivative thereof, wherein R1, R2, V1, V2, and V3 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of AKT, PKA, PDK1, p70S6K, or ROCK kinase, mammalian protein kinases involved in proliferative and neurodegenerative disorders. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of utilizing those compositions in the treatment of various disorders.

Structure-Based Design, Synthesis, and Antimicrobial Activity of Indazole-Derived SAH/MTA Nucleosidase Inhibitors

The structure-based design, synthesis, and biological activity of a novel indazole-containing inhibitor series for S-adenosyl homocysteine/methylthioadenosine (SAH/MTA) nucleosidase are described. Use of 5-aminoindazole as the core scaffold provided a structure-guided series of low nanomolar inhibitors with broad-spectrum antimicrobial activity. The implementation of structure-based methodologies provided a 6000-fold increase in potency over a short timeline (several months) and an economy of synthesized compounds.

Heterocyclic substituted 2-methyl-benzimidazole antiviral agents

The present invention concerns antiviral compounds, their methods of preparation and their compositions, and use in the treatment of viral infections. More particularly, the invention provides heterocyclic substituted 2-methylbenzimidazole derivatives for the treatment of respiratory syncytial virus infection.

Synthesis of Pyrazoloacridin-9(10H)-ones

Eight pyrazoloacridin-9(10H)-ones were prepared in a three step procedure from 5- and 6-nitroindazoles.Palladium catalysed hydrogenation of nitroindazoles afforded the corresponding 5- and 6-aminoindazoles.These, in turn, reacted with o-chlorobenzoic acid under the conditions of the Ullman reaction to give anthranilic acids.Cyclisation of these acids by means of sulfuric acid led to the title compounds.If phosphoryl chloride was used, instead of sulfuric acid, a 9-chloroacridine derivative was obtained.All the compounds were characterised by 1H NMR spectroscopy.

Synthesis and anthelmintic activity of indazoles and nitroindazoles

The synthesis and anthelmintic evaluation of indazole aminomethylated compounds and ureas were performed. The anthelmintic activity of ureas against Syphacia obvelata was pointed out.