41335-50-6Relevant academic research and scientific papers
Alkylation of Sulfonamides with Trichloroacetimidates under Thermal Conditions
Wallach, Daniel R.,Chisholm, John D.
, p. 8035 - 8042 (2016/09/12)
An intermolecular alkylation of sulfonamides with trichloroacetimidates is reported. This transformation does not require an exogenous acid, base, or transition metal catalyst; instead the addition occurs in refluxing toluene without additives. The sulfonamide alkylation partner appears to be only limited by sterics, with unsubstituted sulfonamides providing better yields than more encumbered N-alkyl sulfonamides. The trichloroacetimidate alkylating agent must be a stable cation precursor for the substitution reaction to proceed under these conditions.
Regioselective alkylation of saccharin with alcohols under Mitsunobu conditions
Wang, Xiaolong,Ma, Yanying,Ju, Tingting
, p. 417 - 419 (2013/09/12)
The regioselective Mitsunobu alkylation of saccharin with various alcohols has been examined. The N/O-alkylation is dependent on the steric hindrance of the alcohols, that is, less sterically hindered alcohol preferentially afford N-alkylated saccharin an
Sulfonamide ligands attained through opening of saccharin derivatives
Robinson, Richard I.,Fryatt, Ross,Wilson, Claire,Woodward, Simon
, p. 4483 - 4489 (2007/10/03)
Literature N-alkylsaccharins (saccharin-R2) have been shown in some cases to be O-alkylated regioisomers by crystallography (3 structures). The genuine former species react with (S)-H2NCHR1CH 2OH at 101°C in dio
