41339-01-9

Upstream product

• 70-11-1 α-bromoacetophenone 
• 5351-69-9 4-Phenyl-3-thiosemicarbazide 
• 14673-56-4 acetone-4-phenylthiosemicarbazone 
• 110152-93-7 2-isopropylidenehydrazono-3,4-diphenyl-2,3-dihydro-1,3-thiazole 

Downstream Products

• 54809-89-1 (3-amino-4-phenyl-3H-thiazol-2-ylidene)-phenyl-amine 
• 41338-80-1 2-(4-hydroxy-3-phenylcarbamoyl-naphthalen-1-ylazo)-3,4-diphenyl-thiazolium betaine 
• 67399-36-4 2-(4-nitrobenzylidenehydrazono)-3,4-diphenyl-2,3-dihydro-1,3-thiazole 
• 67399-20-6 2-benzylidenehydrazono-3,4-diphenyl-2,3-dihydro-1,3-thiazole 
• 54809-89-1 2-phenylimino-4-phenyl-2,3-dihydro-1,3-thiazol-3-amine 
• 54809-90-4 C₂₂H₁₆N₄O₂S 
• 1649989-05-8 2-phenylamino-4-phenyl-5-nitroso-1,3-thiazole 
• 1649989-07-0 2-phenylamino-4-phenyl-5-(benzylideneamino)-1,3-thiazole 

Relevant academic research and scientific papers

Cyclization of 4-phenylthiosemicarbazide with phenacylbromide revisited. Formation of 1,3,4-thiadiazines and of isomeric 1,3-thiazoles

The cyclization of 4-phenylthiosemicarbazide with phenacylbromide, carried out in refluxing ethanol, afforded 1,3,4-thiadiazine 1 as the major product. In contrast to a previous report, 2-phenylimino-4-phenyl-2,3-dihydro-1,3-thiazol-3- amine (2) and not 2

THE USES OF 4-PHENYL-3-THIOSEMICARBAZIDE IN HETEROCYCLIC SYNTHESIS: NOVEL SYNTHESIS OF THIAZOLE, PYRAZOLE AND 1,3,4-THIADIAZINE DERIVATIVES

4-Phenyl-3-thiosemicarbazide derivatives 1a-c react with phenacylbromide, 3-bromoacetylcoumarin and monochloroacetic acid to afford thiazole derivatives 3a-c, 8a-c and 12a-c, respectively.Reaction of 1a with ethyl acetoacetate afford the condensated produ