14673-56-4

Basic information

• Product Name: Acetone 4-phenyl thiosemicarbazone
• Synonyms: Acetone 4-phenyl thiosemicarbazone
• CAS NO: 14673-56-4
• Molecular Formula: C₁₀H₁₃N₃S
• Molecular Weight: 207.2953
• Mol File: 14673-56-4.mol

Chemical Properties

• Boiling Point: 306.6°Cat760mmHg
• Flash Point: 139.2°C
• Appearance: /
• Density: 1.11g/cm³
• Vapor Pressure: 0.000763mmHg at 25°C
• Refractive Index: 1.582
• CAS DataBase Reference: Acetone 4-phenyl thiosemicarbazone(CAS DataBase Reference)
• NIST Chemistry Reference: Acetone 4-phenyl thiosemicarbazone(14673-56-4)
• EPA Substance Registry System: Acetone 4-phenyl thiosemicarbazone(14673-56-4)

Safety Data

• Hazardous Substances Data: 14673-56-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H13N3S/c1-8(2)12-13-10(14)11-9-6-4-3-5-7-9/h3-7H,1-2H3,(H2,11,13,14)

Upstream product

• 62-53-3 aniline 
• 1752-30-3 Acetone thiosemicarbazone 
• 108-88-3 toluene 
• 5351-69-9 4-Phenyl-3-thiosemicarbazide 
• 67-64-1 acetone 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 865316-65-0 3-phenyl-thiazolidine-2,4-dione-2-isopropylidenehydrazone 
• 110152-93-7 (Z)-3,4-diphenyl-2-(propan-2-ylidenehydrazono)-2,3-dihydrothiazole 
• 67618-48-8 2-isopropylidenehydrazono-3-phenyl-2,3-dihydro-thiazole-5-carboxylic acid ethyl ester 
• 25688-07-7 2,5-Dihydro-5,5-dimethyl-2-(phenylimino)-1,3,4-thiadiazole 
• 3161-76-0 2-isopropylidenehydrazono-4-methyl-3-phenyl-2,3-dihydro-thiazole-5-carboxylic acid ethyl ester 
• 89578-94-9 C₁₁H₁₅N₃S 
• 21076-38-0 1-isopropyl-4-phenyl thiosemicarbazide 
• 25687-97-2 4,5-Dihydro-3,3-dimethyl-4-phenyl-3H-1,2,4-triazole-5-thione 
• 89579-03-3 2,2-Dimethyl-5-phenylamino-[1,3,4]thiadiazole-3-carboxylic acid phenylamide 
• 95881-68-8 1,1-Dimethyl-3-[(E)-phenylimino]-[1,2,4]triazolo[1,2-c][1,3,4]thiadiazole-5,7-dione 
• 88614-17-9 3-isopropylideneamino-2-phenylimino-1,3-thiazolidin-4-one 
• 5533-44-8 N⁵-phenyl-tetrazole-1,5-diamine 
• 80269-73-4 6-chloro-2,2-dimethyl-4-phenyl-1-thia-4-azaspiro<2.3>hexan-5-one 
• 80269-74-5 4-isopropylidene-2-oxo-1,3,3-triphenylazetidine 

Relevant articles and documents

Square planar Ni(ii) complexes of acetone: N 4-phenyl-thiosemicarbazone and in situ generated benzoyl thiosemicarbazide ligands: Synthesis, spectral and structural characterizations, thermal behaviour and electrochemical studies

Two novel square planar complexes [Ni(Hapt)2] (1) and [Ni(btsc)] (2) have been synthesized from acetone N4-phenyl-thiosemicarbazone (Hapt) and benzoyl-3-thiosemicarbazide (Hbtsc) by the reaction of nickel(ii) salt. The ligand and complexes have been characterized by various physicochemical methods. Complexes 1 and 2 crystallize in the monoclinic and orthorhombic systems with space group C2/c and Pbcn, respectively. In complexes 1 and 2 the nickel centre is coordinated through the nitrogen and sulphur atoms forming a square planar geometry. Complexes 1 and 2 are stabilized via various types of intermolecular interactions. The course of the thermal degradations of complexes 1 and 2 has been investigated by TGA which indicated that a metal sulphide/oxide is formed as the final residue. Cyclic voltammetric studies show that complex 1 exhibits a reversible Ni(ii)/Ni(iii) redox process at 0.525 V (E1/2 value at 20 mV s-1) while complex 2 shows reversible redox behavior with an E1/2 value of 0.43 V. Furthermore, efficient electrocatalytic properties of complexes 1 and 2 toward the oxidation of hydrazine and methanol are demonstrated after immobilizing the complexes into Nafion films. The electrocatalytic properties may find applications in industry, in methanol sensing and in methanol fuel cells.

Morphological and: In vitro evaluation of programmed cell death in MCF-7 cells by new organoruthenium(II) complexes

Cyclopentadienyl ruthenium(ii) thiosemicarbazone complexes with the general formula [Ru(η5-C5H5)(Ac-tsc)PPh3]·Cl (1), [Ru(η5-C5H5)(Ac-mtsc)PPh3]·Cl (2), [Ru(η5-C5H5)(Ac-etsc)PPh3]·Cl (3) and [Ru(η5-C5H5)(Ac-ptsc)PPh3] (4) were synthesized and characterized by various spectroscopic techniques (1H NMR, 13C NMR, IR and UV-vis). The molecular structures of the representative complexes 2 and 4 were studied by single-crystal X-ray diffraction. The interactions of all the ligands and complexes with calf thymus DNA (CT-DNA) and bovine serum albumin (BSA) were studied using UV-vis and fluorescence emission spectroscopy. The results of binding studies revealed that the effective binding potentials of the complexes were higher than those of their parent ligands. All the new complexes 1-4 were investigated for their in vitro cytotoxic activity against MCF-7 human breast cancer cell line. All the complexes significantly inhibited cell proliferation in MCF-7 cells in a dose-dependent manner. Cytological observations via an inverted phase contrast microscope and a Hoechst 33342/PI dual-staining assay showed typical apoptotic morphology of cancer cells upon treatment with complexes 2 and 3. It can thus be suggested that the complexes 2 and 3 are modulated by apoptosis. The findings of the present study indicated that complexes 2 and 3 may become potent drugs for the treatment of cancer-related diseases only after further investigation.

Synthesis, characterization, and anticancer activity of a series of ketone-N4-substituted thiosemicarbazones and their ruthenium(II) arene complexes

A series of ketone-N4-substituted thiosemicarbazone (TSC) compounds (L1-L9) and their corresponding [(η6-p-cymene)Ru II(TSC)Cl]+/0 complexes (1-9) were synthesized and characterized by NMR, IR, elemental analysis, and HR-ESI-mass spectrometry. The molecular structures of L4, L9, 1-6, and 9 were determined by single-crystal X-ray diffraction analysis. The compounds were further evaluated for their in vitro antiproliferative activities against the SGC-7901 human gastric cancer, BEL-7404 human liver cancer, and HEK-293T noncancerous cell lines. Furthermore, the interactions of the compounds with DNA were followed by electrophoretic mobility spectrometry studies.

Diorganotin(IV) complexes with acetone N(4)-phenylthiosemicarbazone (Haptsc) as ligand. The crystallographic structures of [Sn(CH3) 2(aptsc)X] (X=Cl and Br)

The reaction of Haptsc with SnMe2Cl2 and SnMe 2Br2 yielded [Sn(CH3)2(aptsc)Cl] (1) and [Sn(CH3)2(aptsc)Br] (2), respectively. The complexes were characterized by IR an