41339-62-2

Basic information

• Product Name: 1H-INDOLE-3-ETHANOL,4-METHYL-
• Synonyms: 1H-INDOLE-3-ETHANOL,4-METHYL-;2-(4-methyl-1H-indol-3-yl)ethanol
• CAS NO: 41339-62-2
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.23
• Mol File: 41339-62-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-INDOLE-3-ETHANOL,4-METHYL-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-INDOLE-3-ETHANOL,4-METHYL-(41339-62-2)
• EPA Substance Registry System: 1H-INDOLE-3-ETHANOL,4-METHYL-(41339-62-2)

Safety Data

• Hazardous Substances Data: 41339-62-2(Hazardous Substances Data)

Usage

Classification

Indole derivative

Occurrence

Naturally occurring compound found in certain plants, fruits, human and animal tissues

Properties

Antioxidant, anti-inflammatory

Therapeutic Applications

Potential treatment for various diseases, including cancer and neurodegenerative disorders

Role

Involved in the biosynthesis of neurotransmitters and hormones in the body

Chemical Structure

Six-membered benzene ring fused to a five-membered nitrogen-containing ring, conferring unique biological activities.

Upstream product

• 1191-99-7 2,3-dihydro-2H-furan 
• 637-04-7 (3-methylphenyl)hydrazine hydrochloride 
• 425640-05-7 C₁₂H₁₁NO₃ 
• 16096-32-5 4-methyl-1H-indole 

Relevant articles and documents

Enantioselective Construction of Spirooxindole-Fused Cyclopentanes

The present study reports an asymmetric organocatalytic cascade reaction of oxindole derivates with α,β-unsaturated aldehydes efficiently catalyzed by simple chiral secondary amine. Spirooxindole-fused cyclopentanes were produced in excellent isolated yields (up to 98%) with excellent enantiopurities (up to 99% ee) and moderate to high diastereoselectivities. The synthetic utility of the protocol was exemplified on a set of additional transformations of the corresponding spiro compounds. In addition, a study showing the promising biological activity of selected enantioenriched products was accomplished.

Dearomatization of tryptophols via a vanadium-catalyzed asymmetric epoxidation and ring-opening cascade

An enantioselective epoxidation of tryptophols followed by an intramolecular epoxide opening reaction was realized by chiral vanadium catalysts derived from C2 symmetric bis-hydroxamic acid (BHA) ligands. 3a-Hydroxyfuroindoline derivatives with up to 89% yield and 90% ee were obtained under mild reaction conditions.

NOVEL 2,3-DIHYDROINDOLE COMPOUNDS

The invention relates to compounds of the formula I, wherein the variables are as defined in the claims. The compounds are useful in the treatment of a disease where a D4 receptor and/or a 5-HT2A receptor is implicated.