41340-78-7

Basic information

• Product Name: PIPERAZINE-1-CARBOXYLIC ACID DIMETHYLAMIDE
• Synonyms: PIPERAZINE-1-CARBOXYLIC ACID DIMETHYLAMIDE;TIMTEC-BB SBB002583;CBI-BB ZERO/006038;AKOS BBS-00005897;N,N-dimethylpiperazine-1-carboxamide;1-Piperazinecarboxamide,N,N-dimethyl-(9CI);1-(Dimethylcarbamoyl)piperazine;Piperazine-1-carboxylic acid dimethylamide ,98%
• CAS NO: 41340-78-7
• Molecular Formula: C₇H₁₅N₃O
• Molecular Weight: 157.21
• Product Categories: PIPERIDINE;piperazines
• Mol File: 41340-78-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 79-80°C/0.2mm
• Flash Point: 118.9 °C
• Appearance: /
• Density: 1.058 g/cm³
• Vapor Pressure: 0.00586mmHg at 25°C
• Refractive Index: 1.489
• PKA: 8.55±0.10(Predicted)
• CAS DataBase Reference: PIPERAZINE-1-CARBOXYLIC ACID DIMETHYLAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: PIPERAZINE-1-CARBOXYLIC ACID DIMETHYLAMIDE(41340-78-7)
• EPA Substance Registry System: PIPERAZINE-1-CARBOXYLIC ACID DIMETHYLAMIDE(41340-78-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36-22
• Safety Statements: 26-24/25-23
• Hazardous Substances Data: 41340-78-7(Hazardous Substances Data)

Usage

Chemical Properties

White low melting solid

InChI:InChI=1/C7H15N3O/c1-9(2)7(11)10-5-3-8-4-6-10/h8H,3-6H2,1-2H3

Upstream product

• 110-85-0 piperazine 
• 79-44-7 N,N-Dimethylcarbamoyl chloride 
• 215453-81-9 tert-butyl 4-(dimethylcarbamoyl)piperazine-1-carboxylate 

Downstream Products

• 1426918-60-6 4-[6-(4-hydroxy-phenyl)-3-((E)-styryl)-1H-pyrazolo[3,4-b]pyridine-4-carbonyl]-piperazine-1-carboxylic acid dimethylamide 
• 1130154-46-9 4-[(2E)-4-{4-[(3,4-dichlorophenyl)amino]-5,8-dihydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-7(6H)-yl}-4-oxobut-2-en-1-yl]-N,N-dimethylpiperazine-1-carboxamide 
• 882048-04-6 4-[7-(4-formylphenyl)-6-phenylpyrido[2,3-d]pyrimidin-2-yl]-N,N-dimethylpiperazine-1-carboxamide 
• 1027721-48-7 4-[(R)-3-(3-Cyano-phenyl)-2-(naphthalene-2-sulfonylamino)-propionyl]-piperazine-1-carboxylic acid dimethylamide 

Relevant articles and documents

2,5-Disubstituted pyridines as potent GPR119 agonists

A series of 2-piperazinyl-5-alkoxypyridines were synthesized and screened against human GPR119 receptor. Through SAR analysis, compounds containing 2-alkylsulfonylpiperazinyl-5-alkoxypyridines were discovered and found to be potent agonists of the human GPR119 receptor.

CARBAMATE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS

The invention provides novel benzoimidazolone-carboxamide-derived carbamate 5-HT4 receptor agonist compounds of formula (I): wherein R1, R2, R3, R4, a, and b are defined in the disclosure. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.

4-AMINOQUINOLINE-3-CARBOXAMIDE DERIVATIVES AS PDE4 INHIBITORS

Compounds of formula (I) or pharmaceutically acceptable salts thereof: (I) are inhibitors of phosphodiesterase type IV (PDE4) and are of use in the treatment of inflammatory and/or allergic diseases.