41343-01-5

Basic information

• Product Name: 1,2-Propanediol, 2-[4-(2-methylpropyl)phenyl]-
• CAS NO: 41343-01-5
• Molecular Formula: C13H20O2
• Molecular Weight: 208.301
• Mol File: 41343-01-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1,2-Propanediol, 2-[4-(2-methylpropyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Propanediol, 2-[4-(2-methylpropyl)phenyl]-(41343-01-5)
• EPA Substance Registry System: 1,2-Propanediol, 2-[4-(2-methylpropyl)phenyl]-(41343-01-5)

Safety Data

• Hazardous Substances Data: 41343-01-5(Hazardous Substances Data)

Upstream product

• 56374-24-4 (R/S)-4-isobutyl-α-methylstyrene oxide 
• 36039-36-8 2-(4-isobutylphenyl)propan-1-ol 
• 51407-46-6 2-(4-isobutylphenyl)propionaldehyde 
• 34352-86-8 1-isobutyl-4-(prop-1-en-2-yl)benzene 

Downstream Products

• 56374-24-4 (R/S)-4-isobutyl-α-methylstyrene oxide 
• 171417-12-2 (R)-2-(p-isobutylphenyl)-1,2-propanediol 
• 159850-44-9 (S)-2-(4-isobutylphenyl)-1,2-propanediol 
• 114937-30-3 (2S)-2-<4-(2-Methylpropyl)phenyl>propan-1-ol 
• 51146-56-6 (S)-ibuprofen 

Relevant articles and documents

Intramolecular C(sp3)–H Bond Oxygenation by Transition-Metal Acylnitrenoids

This study demonstrates for the first time that easily accessible transition-metal acylnitrenoids can be used for controlled direct C(sp3)-H oxygenations. Specifically, a ruthenium catalyst activates N-benzoyloxycarbamates as nitrene precursors towards regioselective intramolecular C?H oxygenations to provide cyclic carbonates, hydroxylated carbamates, or 1,2-diols. The method can be applied to the chemoselective C?H oxygenation of benzylic, allylic, and propargylic C(sp3)?H bonds. The reaction can be performed in an enantioselective fashion and switched in a catalyst-controlled fashion between C?H oxygenation and C?H amination. This work provides a new reaction mode for the regiocontrolled and stereocontrolled conversion of C(sp3)-H into C(sp3)?O bonds.

Microbiological transformations 43. Epoxide hydrolases as tools for the synthesis of enantiopure α-methylstyrene oxides: A new and efficient synthesis of (S)-ibuprofen

Biohydrolysis of various α-methylstyrene oxide derivatives, differently substituted at the aromatic ring, was investigated using 10 epoxide hydrolases from different origins. Our results indicate that the enantioselectivity of these biohydrolyses strongly depends on the nature of the enzyme and of the substituent. Using some of these enzymes, this approach allows to prepare these epoxides in high optical purity. The potentiality to perform efficient preparative-scale resolution using such a biocatalyst was illustrated by the four-step synthesis of (S)-ibuprofen, a nonsteroidal antiinflammatory drug and household pain killer, one of the top-ten drugs sold worldwide. Using a combined chemoenzymatic strategy, we were thus able to set up a four-step enantioconvergent procedure allowing for the synthesis of this compound in optically pure form and with a 47% overall yield, including the resolution process, due to a possible recycling of the formed diol via chemical racemisation.