41354-03-4

Usage

Uses

Used in Pharmaceutical Industry:
1-Benzyl indazolyl-3-carboxylic acid is used as a pharmaceutical candidate for its potential anticancer properties. Its unique chemical structure allows it to interact with various biological targets, making it a promising agent for the development of new cancer therapies.
Used in Medicinal Chemistry Research:
1-Benzyl indazolyl-3-carboxylic acid is used as a starting point for further research and drug development. Its chemical properties and potential biological activities make it an interesting compound for the synthesis of new drugs and the exploration of novel therapeutic approaches.
Used in Drug Development:
1-Benzyl indazolyl-3-carboxylic acid is used in the development of new drugs targeting various diseases, particularly cancer. Its unique structure and potential biological activities provide a foundation for the design and synthesis of innovative pharmaceuticals with improved efficacy and selectivity.

Upstream product

• 43120-28-1 methyl 1H-indazole-3-carboxylate 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 
• 173600-03-8 benzyl-1H-indazole-3-carboxylic acid methyl ester 

Downstream Products

• 1345965-37-8 C₁₈H₁₇N₃O₂ 
• 1345965-56-1 C₁₉H₁₅N₃O₃ 
• 1345965-54-9 C₁₉H₁₇N₃O₃ 
• 43120-25-8 1-benzyl-1H-indazole 

Relevant academic research and scientific papers

Development of potent serotonin-3 (5-HT3) receptor antagonists. II. Structure-activity relationships of N-(1-benzyl-4-methylhexahydro-1H-1,4- diazepin-6-yl)carboxamides

Our studies on 4-amino-5-chloro-2-ethoxybenzamides led to the discovery that the N-(1,4-dimethylhexahydro-1H-1,4-diazepin-6-yl)benzamide 9 and the 1- benzyl-4-methylhexahydro-1H-1,4-diazepine analogue 10 are potent serotonin-3 (5-HT3) receptor antagonists. Structure-activity relationship (SAR) studies on the influence of the aromatic nucleus of 9 and 10 upon inhibition of the von Bezold-Jarisch reflex in rats are described. Heteroaromatic rings such as pyrrole, thiophene, furan, pyridine, pyridaziae, 1,2-benzisoxazole, indole, quinoline, and isoquinoline rings showed weak 5-HT3 receptor antagonistic activity. Within this series, use of the 1H-indazole ring as an aromatic moiety led to a substantial increase of the activity; the 1H- indazolylcarboxamides 54, 57, 97, and 102 showed potent 5-HT3 receptor antagonistic activity. The optimal compound identified via extensive SAR studies was N-(1-benzyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-1H-indazole- 3-carboxamide (54), whose effect was superior to that of the corresponding benzamide 10 and essentially equipotent to those of ondansetron (1) and granisetron (4).