413597-67-8Relevant academic research and scientific papers
HYDROXAMIC ACID DERIVATIVES AS LPXC INHIBITORS FOR THE TREATMENT OF BACTERIAL INFECTIONS
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Page/Page column 146-147, (2014/10/15)
This invention pertains generally to antibacterial organic compounds of Formula I as described herein, and pharmaceutical compositions containing such compounds. In certain aspects, the invention pertains to treating infections caused by Gram-negative bac
PROCESS SIMPLIFICATION FOR PRECURSOR COMPOUND
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, (2013/10/22)
The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabelled amino acids for use in in vivo imaging procedures such as positron emission tomography (PET). Particularly, the invention relates to a process for preparation of a precursor useful in the preparation of the [18F]-1-amino-3-fluorocyclobutanecarboxylic acid ([18F] FACBC) PET tracer.
PROCESS SIMPLIFICATION FOR PRECURSOR COMPOUND
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, (2012/07/13)
The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabelled amino acids for use in in vivo imaging procedures such as positron emission tomography (PET). Particularly, the invention relates to a process for preparation of a precursor useful in the preparation of the [18F]-1-amino-3- fluorocyclobutanecarboxyiic acid ([18F] FACBC) PET tracer.
PREPARATION OF A 1-AMINO-3-HYDROXY-CYCLOBUTANE-1-CARBOXYLIC ACID DERIVATIVE
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Page/Page column 8, (2012/09/22)
The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabelled amino acids for use in in vivo imaging procedures such as positron emission tomography (PET). Particularly, the invention relates to a process for preparation of a precursor of the [18F]-1-amino-3-fluorocyclobutanecarboxylic acid ([18F] FACBC) PET agent, ensuring that the reaction efficiently goes to completion.
PREPARATION OF PET PRECURSOR
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Page/Page column 9; 10, (2013/02/28)
The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radio labelled amino acids for use in in vivo imaging procedures such as positron emission tomography (PET). Particularly, the invention relates to a process for preparation of a precursor of the [18F]-l-amino-3-fluorocyclobutanecarboxylic acid ([18F] FACBC) PET agent, wherein a hydrogenolysis is performed using a non-gaseous hydrogen source.
Syntheses of new conformationally constrained S-[2-[(1-iminoethyl)amino]ethyl]homocysteine derivatives as potential nitric oxide synthase inhibitors
Wang, Lijuan J.,Grapperhaus, Margaret L.,Pitzele, Barnett S.,Hagen, Timothy J.,Fok, Kam F.,Scholten, Jeffrey A.,Spangler, Dale P.,Toth, Mihaly V.,Jerome, Gina M.,Moore, William M.,Manning, Pamela T.,Sikorski, James A.
, p. 77 - 83 (2007/10/03)
The efficient syntheses of two new types of conformationally constrained S-[2-[(1-iminoethyl)amino]ethyl]homocysteine derivatives, 1-amino-3-[2[(1-iminoethyl)amino]ethylthio]cyclobutane carboxylic acid (5) and (4S)-4-[[2-[(1-Iminoethyl)amino]ethyl]thio]-L
Diastereoselective synthesis of hydantoin- and isoxazoline-substituted dispirocyclobutanoids
Park, Kyung-Ho,Kurth, Mark J.
, p. 3520 - 3524 (2007/10/03)
Synthetic strategies for constructing novel achiral cyclobutanoid isoxazolidinoimidazolidinedione heterocycles, with a generalized structure of II, have been developed via 1,3-dipolar cycloaddition and carbanilide cyclization transformations from methylenecyclobutane 13. The exo methylene cyclobutane system has made the realization of some diasteroselectivity possible, such that the H-bond (Boc-NH) directed product (i.e., 14) was obtained with 3:1 selectivity relative to the non-H-bond directed product (i.e., 15).
Synthesis and Activity of a Potent N-Methyl-D-aspartic Acid Agonist, trans-1-Aminocyclobutane-1,3-dicarboxylic Acid, and Related Phosphonic and Carboxylic Acids
Allan, Robin D.,Hanrahan, Jane R.,Hambley, Trevor W.,Johnston, Graham A. R.,Mewett, Kenneth N.,Mitrovic, Ann D.
, p. 2905 - 2915 (2007/10/02)
We report the synthesis of a series of 3-carboxy-, 3-(carboxymethyl)-, 3-(1o-phosphoalkenyl)-, and 3-(1o-phosphonoalkyl)-1-aminocyclobutane-1-carboxylic acids for evaluation as agonists or antagonists of neurotransmission at excitatory amino acid receptor
