413621-62-2

Usage

General Description

"(1S)-2,2,2-TRIFLUORO-1-(2-FURYL)ETHYLAMINE" is a chemical compound with the molecular formula C7H7F3NO. It is an organofluorine compound that contains a trifluoromethyl group and a furan ring. (1S)-2,2,2-TRIFLUORO-1-(2-FURYL)ETHYLAMINE is a chiral molecule, with a single stereocenter, and exists as a pair of enantiomers. It is commonly used as a building block in organic synthesis and pharmaceutical research, as well as a reagent in the production of various fluorine-containing compounds. The presence of the furan ring in the molecule also gives it potential applications in medicinal chemistry and other fields.

Upstream product

• 110-00-9 furan 
• 75-90-1 2,2,2-Trifluoroacetaldehyde 
• 413599-92-5 (Z)-2,2,2-trifluoro-1-(furan-2-yl)ethanone O-benzyloxime 
• 413600-00-7 (E)-2,2,2-trifluoro-1-(furan-2-yl)ethanone O-benzyloxime 
• 18207-47-1 2-trifluoroacetylfuran 
• 65686-89-7 2,2,2-trifluoro-1-(furan-2-yl)ethanone oxime 
• 65686-89-7 (Z)-2,2,2-trifluoro-1-(furan-2-yl)ethanone oxime 

Relevant academic research and scientific papers

Convenient synthesis of α-trifluoromethyl amines via aminofluoroalkylation of arenes with N-trimethylsilyl α-trifluoroacetaldehyde hemiaminal

Aminofluoroalkylation of various heteroarenes or substituted benzenes with the N-trimethylsilyl hemiaminals, prepared from 1,1,1,3,3,3-hexamethyldisilazane and gaseous trifluoroacetaldehyde, smoothly underwent at room temperature in the presence of a Lewis acid. [(1-Aryl-2,2,2-trifluoro)ethyl]amines or bis[(1-aryl-2,2,2-trifluoro)ethyl]amines were afforded in moderate to high yields.

An asymmetric synthesis of both enantiomers of 2,2,2-trifluoro-1-furan-2-yl-ethylamine and 3,3,3-trifluoroalanine from 2,2,2-trifluoro-1-furan-2-yl-ethanone

The selective conversion of 2,2,2-trifluoro-1-furan-2-yl-ethanone into (E)- and (Z)-oximes and oxime ethers and subsequent oxazaborolidine-catalyzed enantioselective reduction using different amino alcohols furnished both enantiomers of the important chir