41363-39-7Relevant academic research and scientific papers
Preparation method of aromatic amide compound
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Paragraph 0070-0071, (2020/07/15)
The present invention provides a preparation method of an aromatic amide compound. In an organic solvent, under the effect of a catalyst, an aromatic acid compound and an amine source are subjected toa dehydration reaction to obtain the aromatic amide compound, wherein the aromatic acid compound is an aromatic acid, a substituted aromatic acid, a heterocyclic aromatic acid or a substituted heterocyclic aromatic acid; and the substituent group of amide is any substituent group of H, a C1-C8 straight-chain alkyl or branched-chain alkyl group, a benzene ring or an aromatic ring. The aromatic amide compound is an important chemical intermediate, and the synthesis method is mild in reaction condition and high in yield.
Saccharin reaction with cyanide
Drochioiu, Gabi,Deleanu, Calin,Rusu, Elena,Mangalagiu, Ionel
experimental part, p. 315 - 319 (2012/06/01)
A novel reaction between saccharin (1,2-benzisothiazole-3(2H)-one-1,1- dioxide, o-sulfobenzimide, or obenzoic sulfimide) and cyanide to afford an unexpected compound, 2-(cyanosulfonyl)benzamide, has been described. Cyanide ion proved to attack the sulfonyl group of o-sulfobenzimide over 170°C to open the ring and to add to form a new C-S bond. This is an unexpected reaction, as the leading theory of chemical reaction predicts cyanide to be too weak to react with sulfonyl groups. The spectroscopic data and the elemental analyses confirm the structure of the resulted compound and support the mechanism of reaction. The reaction pathway is important from the theoretical point of view, however it might serve both preparative and analytical purposes.
