41372-20-7

Basic information

• Product Name: R-(-)-Apomorphine
• Synonyms: (r)-5,6,6a,7-tetrahydro-6-methyl-4h-dibenzo[de,g]quinoline-10,11-diol;Apomorphine hydrochloride R-(-)-;(6Ar)-5,6,6A,7-tetrahydro-6-methyl-4H-dibenzo(de,G)chinolin-10,11-diol hydrochlorid;4H-Dibenzo(de,G)quinoline-10,11-diol, 5,6,6A,7-tetrahydro-6-methyl-, hydrochloride, hemihydrate, (R)-;Apokyn;Apomorphin hydrochlorid wasser (2/1);Apomorphine Hydrochloride (250 mg);(-)-10,11-Dihydroxy-aporphine Hydrochloride HeMihydrate
• CAS NO: 41372-20-7
• Molecular Formula: C17H17NO2
• Molecular Weight: 267.32
• EINECS: 206-243-0
• Product Categories: Dopamine receptor;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;APOKYN;Inhibitors;Erectile Dysfunction;Agonists;Dopaminergics;Neurotransmitters
• Mol File: 41372-20-7.mol
• Article Data: 0

Chemical Properties

• Melting Point: 285-287 °C(lit.)
• Boiling Point: 473.4 °C at 760 mmHg
• Flash Point: 268.8 °C
• Appearance: white to gray/calcined
• Vapor Pressure: 1.38E-09mmHg at 25°C
• Storage Temp.: Refrigerator
• Solubility: H2O: ~10 mg/mL, clear, yellow-green
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 week.
• Merck: 13,751
• CAS DataBase Reference: R-(-)-Apomorphine(CAS DataBase Reference)
• NIST Chemistry Reference: R-(-)-Apomorphine(41372-20-7)
• EPA Substance Registry System: R-(-)-Apomorphine(41372-20-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 41372-20-7(Hazardous Substances Data)

Usage

Description

Apomorphine (41372-20-7) is an archetypal dopamine pan-receptor agonist. Displays anti-Parkinsons activity in vivo.1 Protects against MPTP-induced neurotoxicity in a mouse mode1,2 In clinical use for Parkinson’s disease.4,5

Chemical Properties

Off-White Solid

Uses

Different sources of media describe the Uses of 41372-20-7 differently. You can refer to the following data:
1. emetic, antiparkinsonian, erextile dysfunction therapy
2. Dopamine (D1 and D2) receptor agonist. Emetic. Antiparkinsonian.
3. R-(?)-Apomorphine hydrochloride hemihydrate is a nonselective dopamine agonist with anti-Parkinsonian and neuroprotective effects in vivo.

Purification Methods

Crystallise the salt from H2O (hemihydrate) and from EtOH. Crystals turn green on exposure to light. (see previous entry). NARCOTIC.

References

1) Merck Index 14:746 2) Millan et al. (2002), Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes; J. Pharmacol. Exp. Therap., 303 791 3) Grunblatt et al. (1999), Apomorphine protects against MPTP-induced neurotoxicity in mice.; Mov. Discord, 14 612 4) Auffret et al. (2017), Apomorphine pump in advanced Parkinson’s disease: Effects on motor and nonmotor symptoms with brain metabolism correlations; J. Neurol. Sci, 372 279 5) Jenner and Katzenschlager (2016), Apomorphine – pharmacological properties and clinical trials in Parkinson’s disease; Parkinsonism. Related. Disord., 33 Suppl. 1:S13

InChI:InChI=1/2C17H17NO2.2ClH.H2O/c2*1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12;;;/h2*2-6,13,19-20H,7-9H2,1H3;2*1H;1H2/t2*13-;;;/m11.../s1