41374-20-3Relevant articles and documents
A diphenylamine or nucleus method for preparing substituted derivatives
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Paragraph 0105-0110; 0120-0125, (2020/05/05)
The invention discloses a preparation method of a diphenylamine or a nucleus-substituted derivative thereof. The method comprises the following steps: in an aprotic polar solvent, performing reaction on an N-acylation aniline or a nucleus-substituted derivative thereof and alkali to form corresponding salts; performing reaction on the salts and a halogeno benzene or a nucleus-substituted derivative thereof to prepare the N-acylation aniline or a nucleus-substituted derivative thereof; and then, preparing the diphenylamine or a nucleus-substituted derivative thereof through de-acylation reaction in the presence of sodium alkoxide. The method has the beneficial effects that three-step reaction of salifying, condensation and de-acylation in one kettle is sequentially carried out, and a separation and purification process of an intermediate product is eliminated, so that the method is short in processes, short in production cycle and high in yield of products.
Process for the manufacture of fluoran compounds
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, (2008/06/13)
A process for the preparation of a fluoran compound of the formula STR1 wherein R, R1, R2 and R4 are each independently hydrogen, halogen, lower alkyl or lower alkoxy, R3 is hydrogen, halogen, lower alkyl, lower alkoxy or --NX3 X4, or (R1 and R2) or (R3 and R4) each pair together with the carbon atoms to which they are attached, form a fused benzene nucleus, X1, X2, X3 and X4 are each independently hydrogen, alkyl containing not more than 12 carbon atoms which is unsubstituted or substituted by cyano, halogen, hydroxy, tetrahydrofuryl or lower alkoxy, or are cycloalkyl, aryl or aralkyl or (X1 and X2) or (X3 and X4) are each independently together with the nitrogen to which are attached a 5- or 6-membered heterocyclic ring, and the ring A is unsubstituted or substituted by halogen, nitro, lower alkyl, lower alkylthio, lower alkoxy, lower alkoxycarbonyl, amino, mono-lower alkylamino, di-lower alkylamino or lower alkyl carbonylamino, which process comprises (1) reacting a ketonic acid of the formula STR2 with a substituted phenol derivative of the formula STR3 wherein Z is hydrogen, lower alkyl, formyl or lower alkanoyl and A, R, R1, R2, R3, R4, X1 and X2 have the given meanings, (2) adding the reaction product to an aqueous-organic liquor containing a non-polar organic solvent and a base at a temperature of 50° to 90° C., (3) separating the organic phase and (4) removing the organic solvent to obtain the fluoran of the formula (1).