41374-62-3

Usage

Uses

Used in Pharmaceutical Industry:
(4-METHOXYPHENYL)AMINO](OXO)ACETIC ACID is used as a pharmaceutical intermediate for its role in the synthesis of various drugs and active pharmaceutical ingredients. Its unique structure, including a substituted phenyl group, an amino group, and a carboxylic acid group, makes it a valuable component in the development of a wide range of pharmaceutical products.
Used in Pain-Relief Medications:
(4-METHOXYPHENYL)AMINO](OXO)ACETIC ACID is used as an active ingredient in pain-relief medications due to its anti-inflammatory and analgesic properties. It helps alleviate pain and reduce inflammation, making it a crucial component in the formulation of various analgesic and anti-inflammatory drugs.
Used in Disease and Disorder Treatment:
(4-METHOXYPHENYL)AMINO](OXO)ACETIC ACID has potential applications in the treatment of various diseases and disorders. Its versatile chemical structure and properties allow it to be explored for use in developing medications targeting a range of health conditions.

InChI:InChI=1/C9H9NO4/c1-14-7-4-2-6(3-5-7)10-8(11)9(12)13/h2-5H,1H3,(H,10,11)(H,12,13)/p-1

Upstream product

• 144-62-7 oxalic acid 
• 104-94-9 4-methoxy-aniline 
• 18522-99-1 ethyl 4'-methoxyoxanilate 
• 4755-77-5 Ethyl oxalyl chloride 
• 17118-74-0 ethyl oxalylchloride 

Downstream Products

• 164596-91-2 Ni(OOCCONHC₆H₄OCH₃)2(H₂O)2 
• 164597-00-6 VO(OOCCONHC₆H₄OCH₃)2(H₂O) 
• 1354933-59-7 C₁₇H₁₄N₂O₅ 
• 20406-12-6 (4-Methoxy-phenylamino)-oxo-acetyl chloride 
• 5416-93-3 4-Methoxyphenyl isocyanate 

Relevant academic research and scientific papers

Supporting-Electrolyte-Free Anodic Oxidation of Oxamic Acids into Isocyanates: An Expedient Way to Access Ureas, Carbamates, and Thiocarbamates

We report a new electrochemical supporting-electrolyte-free method for synthesizing ureas, carbamates, and thiocarbamates via the oxidation of oxamic acids. This simple, practical, and phosgene-free route includes the generation of an isocyanate intermediate in situ via anodic decarboxylation of an oxamic acid in the presence of an organic base, followed by the one-pot addition of suitable nucleophiles to afford the corresponding ureas, carbamates, and thiocarbamates. This procedure is applicable to different amines, alcohols, and thiols. Furthermore, when single-pass continuous electrochemical flow conditions were used and this reaction was run in a carbon graphite Cgr/Cgr flow cell, urea compounds could be obtained in high yields within a residence time of 6 min, unlocking access to substrates that were inaccessible under batch conditions while being easily scalable.

Direct C-H Functionalization of Phenanthrolines: Metal- And Light-Free Dicarbamoylations

A direct method for C-H dicarbamoylations of phenanthrolines has been developed, which is capable of directly installing primary, secondary as well as tertiary amides. This is a significant improvement on the previous direct method, which was limited to primary amides. The metal-, light-, and catalyst-free Minisci-type reaction is cheap, operationally simple, and scalable. We demonstrate that the step efficiency toward dicarbamoylated phenanthroline targets can now be significantly improved.

Direct C3 Carbamoylation of 2H-Indazoles

We developed a novel method for direct C3 carbamoylation of 2H-indazoles using oxamic acids as carbamoyl radical sources. In the presence of ammonium persulfate, carbamoyl radicals were generated from oxamic acids, then used for further reactions with 2H-indazoles to afford the desired products. The reaction proceeds under metal- and catalyst-free conditions. This simple process allows for the efficient synthesis of C3 carbamoylated 2H-indazoles, which are important scaffolds in organic synthesis.

Synthesis and biological evaluation of novel oxalamido derivatives as caspase-3 inhibitors

A new series of 5-fluoro-3-[(4-substituted-phenylaminooxalyl)-amino]-4-oxo- pentanoic acid, 7a-c, 3-[(4-substitutedphenylaminooxalyl)- amino]-4-oxo-5-(2,3, 5,6-tetrafluoro-phenoxy)-pentanoic acid, 7d-h and 5-(2,6-difluoro-phenoxy)-3- [(substituted-phenylaminooxalyl)-amino]-4-oxo-pentanoic acid, 7i-p have been synthesized from N-(substituted-phenyl)- oxalamic acid, 1 and their activities have been evaluated in vitro. Compounds 7b,c and k show low micromolar inhibitory activity against caspase-3.

Synthesis, structural and biological studies of some oxamic acids and their CoII, NiIIand CuII metal complexes

Six new metal complexes of CoII, NlII and Cu II with N-(4-methoxyphenyl)oxamic acid and N-(4-carboxyphenyl)oxamic acid have been synthesized and characterized by elemental analyses, IR, 1H NMR and electronic spe

CD4 mimics targeting the mechanism of HIV entry

A structure-activity relationship study was conducted of several CD4 mimicking small molecules which block the interaction between HIV-1 gp120 and CD4. These CD4 mimics induce a conformational change in gp120, exposing its co-receptor-binding site. This induces a highly synergistic interaction in the use in combination with a co-receptor CXCR4 antagonist and reveals a pronounced effect on the dynamic supramolecular mechanism of HIV-1 entry.