41382-37-0Relevant academic research and scientific papers
New chemical and radiochemical routes to [18F]Rho6G-DEG-F, a delocalized lipophilic cation for myocardial perfusion imaging with PET
Inkster,Zhang,Akurathi,Belanger,Dubey,Treves,Packard
, p. 1891 - 1896 (2017)
New chemical and radiochemical syntheses are described for the preparation of [18F]Rho6G-DEG-F, an 18F-labeled analogue of the fluorescent dye rhodamine 6G, which has shown promise as myocardidal perfusion imaging agent. Tosylated precursors of [18F]Rho6G-DEG-F amenable to 18F-labeling were obtained either through a two-step synthesis from rhodamine 6G lactone (33% yield), or in one step from rhodamine 575 (64% yield), then purified by preparative C18 chromatography. Manual synthesis of [18F]Rho6G-DEG-F was achieved in a single radiochemical step from either the tosylate salt or the tosylate/formate double salt in DMSO under standard nucleophillic aliphatic 18F-fluorination conditions (K[18F]F/K2CO3/Kryptofix 2.2.2.). Incorporation of the [18F]F- was found to be satisfactory (≥34% by TLC), despite the protic character of the precursor molecules. [18F]Rho6G-DEG-F was manually synthesized in final decay-corrected radiochemical yields of 11-26% (tosylate salt) and 9-21% (tosylate/formate double salt). The protocol was transferred to an automated synthesis unit, where the product was obtained in 3-9% radiochemical yield (n = 3) decay corrected to start-of-synthesis, >99% radiochemical purity, and a molar activity of 122-267 GBq μmol-1 (3.3-7.2 Ci μmol-1).
Isotope edited internal standard method for quantitative surface-enhanced raman spectroscopy
Zhang, Dongmao,Xie, Yong,Deb, Shirshendu K.,Davison, V. Jo,Ben-Amotz, Dor
, p. 3563 - 3569 (2005)
A new isotope edited internal standard (IEIS) method for quantitative surface-enhanced Raman spectroscopy (SERS) is demonstrated using rhodamine 6G (R6G-d0) and rhodamine 6G (R6G-d4) edited with deuterium. The reproducibility and accuracy of the IEIS method is investigated both under optical resonance (SERRS) and non-resonance (SERS) conditions. A batch-to-batch concentration measurement reproducibility of better than 3% is demonstrated over a concentration range of 200 pM-2 μM with up to a factor of 3 difference between the concentration of the analyte and its IEIS. The superior performance of the IEIS method is further illustrated by comparing results obtained using absolute SERS/SERRS intensify calibration (with no internal standard) or using adenine (rather than R6G-d4) as an internal standard for R6G concentration quantization. Potential biomedical gene expression and comparative proteomic applications of the IEIS method are discussed.
An Expedient Synthesis of Cationic Rhodamine Fluorescent Probes Suitable for Conjugation to Amino Acids and Peptides
Afonso, Carlos A. M.,Santhakumar,Lough, Alan,Batey, Robert A.
, p. 2647 - 2654 (2003)
Rhodamine 19 benzyloxycarbonylmethyl ester bromide 8 and rhodamine 19 4-chloromethyl-1-phenylmethyl ester chloride 12 act as precursors to cationic fluorescent probes. Molecules containing free amine or carboxylate functional groups, respectively, can be attached in a one-step procedure, yielding the desired probes without the need for chromatographic purification. As a proof of concept the method was applied to the attachment of amino acid and dipeptide residues through either the N- or C-termini. The precursor molecules 8 and 12 are readily synthesized from the inexpensive, commercially available dye rhodamine 6G.
Nitric oxide donors, preparation and applications of nitric oxide donors
-
Paragraph 0157-0159, (2018/03/24)
The invention relates to nitric oxide donors, preparation and applications of the nitric oxide donors. In particular, the invention provides compounds which have structures represented by a formula I, wherein R2 is H, a C3-C8 naphthenic group or C1-C6 alkyl which is substituted by 1-2 materials optionally selected from C1-C4 alkoxy, -S(O)2-OH, and a substituent group of hydroxyl, and N is connected with a benzene ring of a fluorophore molecule. The invention also provides preparation methods for the compounds represented by the formula I, compositions containing the compounds represented in the formula I, and the applications of the compounds which are used as the nitric oxide donors.
Fluorescent and colorimetric detection of acid vapors by using solid-supported rhodamine hydrazides
Kang, Shincheol,Kim, Sungwook,Yang, Young-Keun,Bae, Shinhyo,Tae, Jinsung
supporting information; experimental part, p. 2010 - 2012 (2009/07/17)
Rhodamine hydrazide-based chemosensors that can detect volatile acidic gases in solid state have been developed. The rhodamine hydrazide probes adsorbed on filter paper respond fluorescently and colorimetrically only to volatile acidic gases but not to organic bases nor to other volatile organic compounds (VOCs). Diethyl chlorophosphate (DCP), one of model compounds used for the studies of Chemical Warfare Agent (CWA), could also be detected by using this method.
