41388-41-4Relevant academic research and scientific papers
An easy access to homopropargylic ethers
Guedin-Vuong, Denis,Nakatani, Yoichi
, p. 245 - 252 (2007/10/02)
Chloromethyl ethers, obtained from alcohols, formaldehyde and HCl, react regioselectively, as shown previously in one case by L.Miginiac, with allenyl aluminium reagents derived from propargyl bromides and aluminium, to give homopropargyl ethers.No evidence for the presence of allenyl ethers was obtained in the cases described.This condensation is used to obtain a protected acetylenic synthon 1, required for the synthesis of an ecdysteroid analogue (1).
