41389-16-6Relevant academic research and scientific papers
TRPV1 ANTAGONISTS
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Page/Page column 34, (2009/05/28)
Compounds of formula (I) wherein R1, R2, R4, and W are defined in the description are TRPV 1 antagonists with CNS penetration. Compositions comprising such compounds and methods for treating conditions and disorders using
Synthesis and affninity evaluation for AT1 receptor of phenylsalicylaldoxime-derivatives structurally related to sartans
Rapposelli, Simona,Cuboni, Serena,Digiacomo, Maria,Lucacchini, Antonio,Minutolo, Filippo,Trincavelli, Maria Letizia,Balsamo, Aldo
experimental part, p. 1467 - 1477 (2009/04/11)
In this work we reported thy synthesis of new potential AT1 antagonists through the replacement of the biphenyltetrazole portion of the losartan with biphenylaldoximic (2) and phenylsalicylaldoximic (3a) moieties. Moreover, also the trifluoromethylpyrazol
Monoaryl-substituted salicylaldoximes as ligands for estrogen receptor β
Minutolo, Filippo,Bellini, Rosalba,Bertini, Simone,Carboni, Isabella,Lapucci, Annalina,Pistolesi, Letizia,Prota, Giovanni,Rapposelli, Simona,Solati, Francesca,Tuccinardi, Tiziano,Martinelli, Adriano,Stossi, Fabio,Carlson, Kathryn E.,Katzenellenbogen, Benita S.,Katzenellenbogen, John A.,Macchia, Marco
, p. 1344 - 1351 (2008/09/21)
Salicylaldoximes possess a hydrogen-bonded pseudocyclic A′ ring in place of the typical phenolic A ring that is characteristic of most estrogen receptor (ER) ligands. Monoaryl-substituted salicylaldoximes were obtained by replacing the phenol moiety (ring
1-(PIPERIDIN-4-YL)-1H-INDOLE DERIVATIVE
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Page/Page column 33; 73-74, (2010/11/28)
The present invention provides a compound represented by the formula (1) or a pharmacologically acceptable salt thereof, or a hydrate thereof (provided that a compound in which all of R4a, R4b, and R4c are hydrogen atoms is excluded.): [wherein R1 represents a hydrogen atom, R2 represents a hydrogen atom, R3 represents the formula: wherein R4a, R4b, and R4c are the same as or different from each other and each represents a hydrogen atom, a C1-6 alkyl group or a C1-6 alkoxy group, etc.]
The thermal [3, 3] claisen rearrangement of the 3-substituted phenyl allyl and propargyl ethers. The synthesis of 4-halobenzo[b]furans
Box, Vernon G. S.,Meleties, Panayiotis C.
, p. 2173 - 2183 (2007/10/03)
The thermal [3, 3] Claisen rearrangement of the 3-substituted phenyl allyl and propargyl ethers is regioselective. The major product of the reaction incorporates a 1, 2, 3-trisubstituted benzene ring. The 2-allenylphenol intermediates can be manipulated i
